productdatasheet
Thymidylatesynthase(TS)isanintracellularenzymecriticalfordenovosynthesisofDNA.Incancer,expressionofTSisoftenelevatedandbecomesfurtherelevatedasaresultoftreatmentwiththemostcommonlyusedchemotherapeutic,5-fluorouracil(5-FU).Resistanceorlackofresponseto5-FUisattributedtotheelevationofTSactivity.OverexpressionofTShasbeendemonstratedinmanytypesoftumorsincludingbreast,colon,gastricandmelanomaandisusuallypredictiveofshortenedsurvivaltime.
E.coli.
TheseantibodiesspecificallyrecognizehumanTS(36kDa).Theydonotcross-reactwithratTS.
Immunohistochemistry:useat5-10ug/mlonfrozensections(reactivityonparaffin-embeddedsectionshasnotbeendetermined).
Immunoblotting:useat5-10ug/ml.ELISA:useat2-5ug/ml(optimizedforTSonsolidphaseat5ug/ml).
Immunoprecipitation:use#34002onlyat5-10ug/ml.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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