Cefixime trihydrate is a broad spectrum third generation cephalosporin targeting a wide range of gram positive and gram negative organisms. Cefixime trihydrate is especially useful against pathogens responsible for causing ear, nose, and throat infections such as Haemophilus influenzae and Moraxella catarrhalis.
125110-14-7
C16H15N5O7S2 • 3 H2O
507.50
Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Cefixime however, is resistant to many β-lactamases encoded by β-lactam resistant strains.
-20°C
2941.90.5000
Powder
Light yellow crystalline powder
Synthetic
9.0-12.0%
2.6-4.1
-75° to -88°
(On Dried Basis): 950-1030 µg/mg
Chromatographic Purity:
Individual Impurity: ≤1.0%
Total Impurities: ≤2.0%
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