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InvivoGen/LL-37/tlrl-l37

LL-37

LL-37Unit sizeCat. codeDocsPrice
Antimicrobial peptide
1 mg
tlrl-l37
TDSMSDS
¥4,199.00
Please contact our distributor
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  • About
  • Specifications
  • Contents
  • Citations
  • Related products

LL-37: Antimicrobial peptide

LL-37, also known as hCAP18, is the C-terminal part of the only human cathelicidin identified to date called human cationic antimicrobial protein (hCAP).

LL-37 exhibits a variety of immunomodulatory functions such as bactericidal action, chemotaxis, activation of chemokine secretion and antisepsis effect [1].The synthetic LL-37 peptide has been shown to suppress the inflammatory response induced by LPS and other TLR ligands [2].

 

References:

1. Scott MG. et al., 2002. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol. 169(7):3883-91.2. Mookherjee N. et al., 2006. Modulation of theTLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol. 176(4):2455-64.

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Specifications

Working concentration: 1 -50 µg/ml

Solubility: Water (1 mg/ml)

Amino acid sequence: LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

Molecular formula: C205H340N60O35

Molecular weight: 4493.37

Purity: ≥ 95 % (UHPLC)

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Contents

LL-37 is provided lyophilized.

  • 1 mg synthetic LL-37
  • 1.5 ml endotoxin-free water

room temperature LL-37 is shipped at room temperature.

store Store at -20°C.

stable Lyophilized product is stable 6 months when properly stored.

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Citations

RNase 7 promotes sensing of self-DNA by human keratinocytes and activates an antiviral immune response.

2020 J Invest Dermatol. DOI: 10.1016/j.jid.2019.09.029

RNase 7 promotes sensing of self-DNA by human keratinocytes and activates an antiviral immune response.

Kopfnagel V. et al.

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis.

2020 Nat Commun. DOI: 10.1038/s41467-019-13756-4

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis.

Herster F. et al.

Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis.

2019 Sci Rep.DOI: 10.1038/s41598-019-42751-4

Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis.

Simonin J. et al.

Differential Expression of Antimicrobial Peptides in Streptococcus pneumoniae Keratitis and STAT3-Dependent Expression of LL-37 by Streptococcus pneumoniae in Human Corneal Epithelial Cells.

2019 Pathogens. DOI: 10.3390/pathogens8010031.

Differential Expression of Antimicrobial Peptides in Streptococcus pneumoniae Keratitis and STAT3-Dependent Expression of LL-37 by Streptococcus pneumoniae in Human Corneal Epithelial Cells.

Sharma P. et al.

Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1.

2019 Viruses DOI: 10.3390/v11010077.

Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1.

Roy M. et al.

LL-37 disrupts the Kaposi's sarcoma-associated herpesvirus envelope and inhibits infection in oral epithelial cells.

2019 Antiviral Res. DOI: 10.1016/j.antiviral.2018.07.025

LL-37 disrupts the Kaposi's sarcoma-associated herpesvirus envelope and inhibits infection in oral epithelial cells.

Brice D.C. et al.

Topical Treatment of Rosacea with Ivermectin Inhibits Gene Expression of Cathelicidin Innate Immune Mediators, LL-37 and KLK5, in Reconstructed and Ex Vivo Skin.

2017 Dermatol Ther (Heidelb). DOI: 10.1007/s13555-017-0176-3

Topical Treatment of Rosacea with Ivermectin Inhibits Gene Expression of Cathelicidin Innate Immune Mediators, LL-37 and KLK5, in Reconstructed and Ex Vivo Skin.

Thibaut de Ménonville S. et al.

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