Deprecated: Creation of dynamic property cls_session::$session_data_table is deprecated in /www/sites/www.188bio.com/index/systems/cls_session.php on line 49
Adipogen/(R)-BI-2536/SYN-1019-M100/100 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线
产品资料

Adipogen/(R)-BI-2536/SYN-1019-M100/100 mg

MoreInformation
ProductDetails
Synonyms(R)-BI2536
ProductTypeChemical
Properties
FormulaC28H39N7O3
MW521.7
CAS755038-02-9
PurityChemicals≥95%
AppearanceSolid.
SolubilitySolubleinDMSO,Ethanol
DeclarationManufacturedbySynKinase.
OtherProductDataTarget:Plk1|KinaseGroup:Other|Substrate:Serine-Threonine

ClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKeyXQVVPGYIWAGRNI-JOCHJYFZSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StABIlityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
Polo-likekinase1(Plk1)isaregulatorofthecellcyclethathasbeenimplicatedinthepathologyofmanycancers.BI-2536isapotentandselectivesmall-moleculeinhibitorofmammalianPlk1.IthasinhibitoryactivityatsubnanomolarconcentrationsandinhibitstumorgrowthinmultipletumorlineswithIC(50)valuesbelow1µM.BI-2536alsoshowsan>1,000-foldselectivityforPIK1versusalargepanelofotherkinases.BI-2536alsodemonstratedlowKdvaluesagainstsisterkinasesPLK2andPLK3.PreclinicalstudiesinhumancancercelllineshaveshownthatBI2536disruptsspindleassembly,resultinginmitoticarrestandinducingapoptosis.BI-2536iscurrentlyinclinicaltrialsagainstseveraltypesofsolidtumorcancers.
ProductReferences
  1. BI2536,apotentandselectiveinhibitorofpolo-likekinase1,inhibitstumorgrowthinvivo:M.Steegmaier,etal.;Curr.Biol.17,316(2007)
  2. PharmacophoremodelingandvirtualscreeningfordesigningpotentialPLK1inhibitors:H.Y.Wang,etal.;Bioorg.Med.Chem.Lett.18,4972(2008)
  3. HittoLeadoptimizationofanovelclassofsquarate-containingpolo-likekinasesinhibitors:Q.Zhang,etal.;Bioorg.Med.Chem.Lett.22,7615(2012)
  4. HDACinhibitorsincreaseNRF2-signalingintumourcellsandblunttheefficacyofco-adminsteredcytotoxicagents:M.McMahon,etal.;PLoSOne9,e114055(2014)
新闻动态
行业前沿
技术文章
最新产品