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Adipogen/CYC116/SYN-1034-M005/5 mg

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ProductDetails
SynonymsCYC-116
ProductTypeChemical
Properties
FormulaC18H20N6OS
MW368.5
CAS693228-63-6
PurityChemicals≥95%
AppearanceSolid.
SolubilitySolubleinDMSOorethanol.
DeclarationManufacturedbySynKinase.
OtherProductDataTarget:AuroraA|KinaseGroup:Other|Substrate:Serine-Threonine

ClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKeyGPSZYOIFQZPWEJ-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StABIlityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
CYC116isanorallyactivesmallmoleculemulti-kinaseinhibitorwithanti-neoplasticactivity.CYC116inhibitsAurorakinasesA/Bandvascularendothelialgrowthfactorreceptor2(VEGFR2),resultingindisruptionofthecellcycle,rapidcelldeath,andtheinhibitionofangiogenesis.
ProductReferences
  1. Discoveryanddevelopmentofaurorakinaseinhibitorsasanticanceragents:J.R.Pollard&M.J.Mortimore;J.Med.Chem.52,2629(2009)
  2. Selectivitydata:assessment,predictions,concordance,andimplications:C.Gao,etal.;J.Med.Chem.56,6991(2013)
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