Active Motif 抗体 抗原 试剂盒 全国总代_Active Motif 代理,Active Motif 全国,Active Motif 代理,Active Motif 代理,Active Motif 区域_供应信息_蚂蚁淘生物网

出版应用/物种/样本/稀释参考文献免疫细胞化学; 人类; 1:250; 图1aFarhy C, Hariharan S, Ylanko J, Orozco L, Zeng F, Pass I, et al. Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape. elife. 2019;8: pubmed 出版商 免疫细胞化学; 小鼠; 图2s1d, 3gDel Rosario B, Kriz A, Del Rosario A, Anselmo A, Fry C, White F, et al. Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition. elife. 2019;8: pubmed 出版商 免疫细胞化学; 小鼠; 1:500; 图1aInoue A, Chen Z, Yin Q, Zhang Y. Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells. Genes Dev. 2018;32:1525-1536 pubmed 出版商 免疫细胞化学; 小鼠; 图8Brideau N, Coker H, Gendrel A, Siebert C, Bezstarosti K, Demmers J, et al. Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome. Mol Cell Biol. 2015;35:4053-68 pubmed 出版商 染色质免疫沉淀; 人类免疫印迹; 人类; 图st2Tiffen J, Gunatilake D, Gallagher S, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023-36 pubmed 出版商 染色质免疫沉淀; 人类; 图6Liu X, Chen X, Rycaj K, Chao H, Deng Q, Jeter C, et al. Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells. Oncotarget. 2015;6:23959-86 pubmed 免疫组化; 小鼠; 图2aYamada N, Hasegawa Y, Yue M, Hamada T, Nakagawa S, Ogawa Y. Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome. PLoS Genet. 2015;11:e1005430 pubmed 出版商 免疫细胞化学; 小鼠; 1:1000; 图1Cooper S, Dienstbier M, Hassan R, Schermelleh L, Sharif J, Blackledge N, et al. Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment. Cell Rep. 2014;7:1456-1470 pubmed 出版商 Healy E, Mucha M, Glancy E, Fitzpatrick D, Conway E, Neikes H, et al. PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation. Mol Cell. 2019;76:437-452.e6 pubmed 出版商 Wang S, Zhang C, Hasson D, Desai A, SenBanerjee S, Magnani E, et al. Epigenetic Compensation Promotes Liver Regeneration. Dev Cell. 2019;: pubmed 出版商 Harutyunyan A, Krug B, Chen H, Papillon Cavanagh S, Zeinieh M, De Jay N, et al. H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. Nat Commun. 2019;10:1262 pubmed 出版商 Hiramuki Y, Tapscott S. Identification of SMCHD1 domains for nuclear localization, homo-dimerization, and protein cleavage. Skelet Muscle. 2018;8:24 pubmed 出版商 Du J, Kirk B, Zeng J, Ma J, Wang Q. Three classes of response elements for human PRC2 and MLL1/2-Trithorax complexes. Nucleic Acids Res. 2018;46:8848-8864 pubmed 出版商 Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, et al. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018;70:408-421.e8 pubmed 出版商 Yue M, Ogawa Y. CRISPR/Cas9-mediated modulation of splicing efficiency reveals short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation. Nucleic Acids Res. 2018;46:e26 pubmed 出版商 Yue M, Ogawa A, Yamada N, Charles Richard J, Barski A, Ogawa Y. Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression. PLoS Genet. 2017;13:e1006890 pubmed 出版商 Pawlyn C, Bright M, Buros A, Stein C, Walters Z, Aronson L, et al. Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control. Blood Cancer J. 2017;7:e549 pubmed 出版商 O Hara S, Splinter P, Trussoni C, Pisarello M, Loarca L, Splinter N, et al. ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. J Biol Chem. 2017;292:4833-4846 pubmed 出版商 Kelsey A, Yang C, Leung D, Minks J, Dixon McDougall T, Baldry S, et al. Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST. Genome Biol. 2015;16:208 pubmed 出版商 背景: Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points. Histone H1 is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression.The methylation of histones can occur on two different residues: arginine or lysine. Histone methylation can be associated with transcriptional activation or repression, depending on the methylated residue. Lysine 27 of histone H3 can be mono-, di- or trimethylated (Histone H3 monomethyl Lys27, Histone H3 dimethyl Lys27 or Histone H3 trimethyl Lys27) by different histone methyltransferases such as EZH2 or NSD3. Methylation of this residue is mainly associated with transcriptional repression.免疫原: 这组蛋白H3三甲基化Lys27通过免疫制备抗体a肽含三甲基化Lys27人的组蛋白H3用途: ChIP, DB, TR-FRET, IF, 免疫沉淀, 免疫印迹储存: Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.产品引用: References: The creation of this antibody was described in Kimura, H. et al. (2008) Cell Struct Func 33: 61-73.This antibody has been used in the following references: ChIP: Ohhata T et al. (2008) Development 135: 227-235; Luco RF et al. (2010) Cell 327: 996-1000.IF: Hayashi-Takanaka Y et al. (2011) Nucl Acid Res 39: 6475-6488.WB: Hayashi-Takanaka Y et al. (2011) Nucl Acid Res 39: 6475-6488.更多信息或购买: Active Motif 产品网页Active Motif787 Kangqiao Road，Building 10, Suite 202，Pudong District，Shanghai, Chinatechchina@activemotif.comhttp://www.activemotif.com86-21-20926090 400-018-8123公司总部: 美国

ActiveMotif抗体抗原试剂盒全国总代

ActiveMotif抗体抗原试剂盒全国总代

ActiveMotif公司是一家致力于研发和生产核细胞分子生物学和表观遗传学研究用试剂的专业公司，也是世界上最大的转录因子试剂生产商和ChIP-seq外包服务供应商。ActiveMotif的产品涉及：表观遗传学相关抗体、Chip级别抗体、重组识别子和催化酶、预甲基化修饰的重组组蛋白、多聚核小体和生物素标记核小体；以及各类染色质分析、转录因子表达调控分析和DNA甲基化分析的试剂盒等。不仅如此，ActiveMotif还为研究者提供专业的表观遗传学服务，特别是Chip-seq的外包服务。公司总部位于美国加州，目前在欧洲，日本，中国设有分公司。产品销售范围覆盖全球30多个国家和地区。

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2017年1月7日公司名称 : Active Motif 其他品牌 : Geneka Biotechnology 产品类型 : 抗体 产品名称 : 组蛋白H3K27me3抗体(单克隆抗体) 目录: 61017 规格: 100微克 价格...