Embelin-Mediated Green Synthesis of Quasi-Spherical and Star-Shaped Plasmonic Nanostructures for Antibacterial Activity, Photothermal Therapy, and Computed Tomographic Imaging | ACS Sustainable Chemistry & Engineering
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Received26 April 2018Revised30 May 2018Published online6 June 2018Published inissue 6 August 2018https://doi.org/10.1021/acssuschemeng.8b01894Copyright © 2018 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views538Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.
Get e-AlertsAbstractPlasmonic nanostructures of silver and gold synthesized by conventional toxic and cumbersome methodologies raise huge concern for their clinical application, which necessitates the use of a greener approach. Herein, embelin, a benzoquinone derivative extracted from the fruits of Embelia tsjeriam-cottam, with immense medicinal value, is used as a reducing and stabilizing agent for the synthesis of quasi-spherical gold and silver nanoparticles as well as gold nanostars. A sunlight-assisted synthesis resulted in embelin-stabilized silver nanoparticles of bimodal size distribution (∼3 and 15 nm) with potent antibacterial activity against Staphylococcus aureus and Escherichia coli. Similarly, embelin was also used for the synthesis of polyhedral gold nanoparticles of 12–15 nm in size and absorbance at 540 nm. These highly faceted and multitwinned gold nanoparticles facilitated the formation of 120 nm sized embelin-stabilized gold nanostars absorbing at NIR wavelength (800 nm). The embelin-stabilized nanoparticles demonstrated excellent compatibility toward cells and human blood. Additionally, the gold nanostars exhibited superior computed tomographic (CT) contrast characteristics and marked photothermal cytotoxicity toward oral epithelial carcinoma cells. This study thus proposes, for the first time, the synthesis of biocompatible plasmonic nanostructures using embelin and their potential use as antibacterial, CT imaging, and photothermal agents.KEYWORDS:Embelin Gold nanoparticle Silver nanoparticle Gold nanostars Antibacterial Photothermal CT imaging Green synthesisSupporting InformationARTICLE SECTIONSJump ToThe Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acssuschemeng.8b01894.Absorbance spectra of embelin, silver nanoparticles, gold nanoparticles (synthesized from standard and extracted embelin) and E-GNS (before and after laser irradiation in photothermal transduction experiment); FEG-TEM images of gold nanoparticles; photograph of stability studies; DLS data; zeta potential profile in buffers; EDAX and XRD of AgNP, AuNP, and E-GNS; 1H NMR spectra of embelin, AgNP, AuNP, and E-GNS; and calculation of photothermal efficiency of E-GNS (PDF)sc8b01894_si_001.pdf (1.78 MB)
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