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Biovendor/PDGF-AB Human E. coli/RBG10266100/100 μg

  • Regulatorystatus:RUO
  • Type:Recombinant
  • Source:E.coli
  • Othernames:Platelet-DerivedGrowthFactor-AB,Glioma-derivedgrowthfactor(GDGF),Osteosarcoma-derivedGrowthFactor(ODGF),PCGF
  • Species:Human

Type

Recombinant

Description

PDGFsaredisulfide-linkeddimersconsistingoftwo12.0–13.5 kDapolypeptidechains,designatedPDGF-A andPDGF-Bchains.ThethreenaturallyoccurringPDGFs,PDGF-AA,PDGF-BBandPDGF-AB,arepotentmitogensforavarietyofcelltypes,includingsmoothmusclecells,connectivetissuecells,boneandcartilagecells,andsomebloodcells.ThePDGFsarestoredinplateletα-granules,andarereleaseduponplateletactivation.ThePDGFsareinvolvedinanumberofBIOLOGicalprocesses,includinghyperplasia,chemotaxis,embryonicneurondevelopment,andrespiratorytubuleepithelialcelldevelopment.TwodistinctsignalingreceptorsusedbyPDGFshavebeenidentifiedandnamedPDGFR-αandPDGFR-β.PDGFR-αisahigh-affinityreceptorforeachofthethreePDGFforms.Ontheotherhand,PDGFR-βinteractswithonlyPDGF-BBandPDGF-AB.RecombinantHumanPDGF-ABisa26.4 kDadisulfide-linkeddimer,consistingofoneαchainandoneβchain(234 totalaminoacids).

Source

E.coli

Purity

98%

BiologicalActivity

TheED50asdeterminedbythedose-dependentstimulationofthymidineuptakebyBALB/c3T3cellsis1 ng/ml,correspondingtoaspecificactivityof1×106units/mg.

Endotoxin

Endotoxinlevelis<0.1 ng/μgofprotein(<1EU/μg).

Reconstitution

Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1–1.0 mg/ml.Donotvortex.Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%BSA)andstoreinworkingaliquotsat –20°Cto –80°C

Storage/Expiration

 –20°C

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