Synonyms | MonoclonalTULP3antibody,Anti-TULP3antibody,MGC45295antibody,TUBL3antibody,TULP3,TULP3,TULP-3,TULP3antibody,TULP-3antibody |
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CrossReactivity | Human |
Applications | IF,IHC,WB |
Immunogen | TULP3antibodywasraisedinMouseusingfulllengthhumanrecombinantproteinofhumanTULP3producedinHEK293Tcellastheimmunogen. |
Host | Mouse |
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Clone | 4E5 |
Isotype | IgG1 |
MethodofPurification | TULP3antibodywaspurifiedbyaffinitychromatography. |
Form&Buffer | SuppliedinPBSbuffer,pH7.3,containing1%BSA,50%glyceroland0.02%sodiumazide. |
Concentration | 0.5-1mg/ml |
Storage | Storeat4degCforshorttermstorage.Aliquotandstoreat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
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UsageRecommendations | IF:1:100,IHC:1:150,WB:1:500-2000 |
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BIOLOGicalSignificance | Thisgeneencodesamemberofthetubbygenefamilyofbipartitetranscriptionfactors.Membersofthisfamilyhavebeenidentifiedinplants,vertebrates,andinvertebrates,andtheyshareaconservedN-terminaltranscriptionactivationregionandaconservedC-terminalDNAandphosphatidylinositol-phosphatebindingregion.TheencodedproteinbindstophosphoinositidesintheplasmamembraneviaitsC-terminalregionandprobablyfunctionsasamembrane-boundtranscriptionregulatorthattranslocatestothenucleusinresponsetophosphoinositidehydrolysis,forinstance,inducedbyG-protein-coupled-receptorsignaling.Itplaysanimportantroleinneuronaldevelopmentandfunction. |
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