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Serotonin N-acetyltransferase/AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.
Titration of the AANAT antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 27-54 from the human protein was used as the immunogen for this AANAT antibody.
Aliquot the AANAT antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
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