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NSJ/ABCA4 Antibody (R32750)/ R32750/ 100 ug

Formulation:

0.5mg/mlifreconstitutedwith0.2mlsterileDIwater

Data:

AvailABIlity1-3businessdays
SpeciesReactivityMouse,Rat
PredictedReactivityHuman
FormatAntigenaffinitypurified
ClonalityPolyclonal(rabbitorigin)
IsotypeRabbitIgG
PurityAntigenaffinity
BufferLyophilizedfrom1XPBSwith2.5%BSA,0.025%sodiumazide
UniProtP78363
ApplicationsWesternBlot:0.5-1ug/ml
LimitationsThisABCA4antibodyisavailableforresearchuseonly.

Description:

ABCA4(ATP-BindingCassette,SubfamilyA,Member4),alsoknownasABCR,isaproteinwhichinhumansisencodedbytheABCA4gene.ABCA4isamemberoftheATP-bindingcassettetransportergenesub-familyA(ABC1)foundexclusivelyinmulticellulareukaryotes.UsingawholegenomerADIationhybridpanel,thisgeneismappedto1p21-p13.Andthisgeneisexpressedexclusivelyinretinaphotoreceptorcells,indicatingthegeneproductmediatestransportofanessentalmoleculeacrossthephotoreceptorcellmembrane.Additionally,itisshowedbyimmunofluorescencemicroscopyandWesternblotanalysisthatABCRispresentinfovealandperipheralcone,aswellasrod,photoreceptors.TheresultssuggestedthatthelossincentralvisionexperiencedbypatientswithStargardtmaculardystrophyarisesdirectlyfromABCR-mediatedfovealconedegeneration.

ApplicationNotes:

OptimaldilutionoftheABCA4antibodyshouldbedeterminedbytheresearcher.

Immunogen:

Aminoacids1890-1927(FLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQR)fromthehumanproteinwereusedastheimmunogenfortheABCA4antibody.

Storage:

Afterreconstitution,theABCA4antibodycanbestoredforuptoonemonthat4oC.Forlong-term,aliquotandstoreat-20oC.Avoidrepeatedfreezingandthawing.
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