RELAPathway Acetylation and Deacetylation of RelA in The Nucleus CHUK CREBBP EP300 IKBKB NFKB1 NFKBIA RELA TNF TNFRSF1A TNFRSF1B TRAF6 IKBKG TRADD RIPK1 FADD HDAC3
no1Pathway Actions of Nitric Oxide in the Heart CHRM1 CHRNA1 CYCSP35 AKT1 FLT1 FLT4 HSP90AA1 KDR KNG1 NOS3 PDE2A PDE3A PDE3B PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKG1 PRKG2 ACTA1 BDKRB2 RYR2 SLC7A1 TNNI1 VEGFA CALM1 CALM2 CALM3 CAV1
gsPathway Activation of cAMP-dependent protein kinase, PKA ADCY1 GNAS GNB1 GNGT1 PRKACA PRKAR1A
CSKPathway Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor ADCY1 CREBBP CSK GNAS GNB1 GNGT1 HLA-DRA HLA-DRB1 LCK PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPRC TRA@ TRB@ ZAP70 CD3D CD3E CD3G CD247 CD4
pkcPathway Activation of PKC through G protein coupled receptor PLCB1 GNAQ NFKB1 NFKBIA PRKCA PRKCB RELA
srcRPTPPathway Activation of Src by Protein-tyrosine phosphatase alpha CSK GRB2 PRKCA PRKCB PTPRA SRC CCNB1 CDC2 CDC25A CDC25B CDC25C
amiPathway Acute Myocardial Infarction COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F2 F2R F7 F10 FGA FGB FGG SERPINC1 ERAF PLAT PLG PROC PROS1 TFPI
granulocytesPathway Adhesion and Diapedesis of Granulocytes CSF3 ICAM1 IFNG IL1A IL8 ITGAL ITGAM ITGB2 PECAM1 SELL SELP SELPLG TNF C5
lympathway Adhesion and Diapedesis of Lymphocytes ICAM1 IL1A IL8 ITGA4 ITGAL ITGB1 ITGB2 PECAM1 SELL VCAM1 CD34
lymphocytePathway Adhesion Molecules on Lymphocyte ICAM1 ITGA4 ITGAL ITGB1 ITGB2 PECAM1 SELE SELL CD44
arapPathway ADP-Ribosylation Factor ARFGEF2 ARFGEF1 KDELR1 KDELR2 KDELR3 CLTB COP COPA ARFGAP3 CYTH4 GPLD1 ARF1 ARFGAP1 GBF1 ASAP2 CYTH3 CYTH2 CYTH1
agrPathway Agrin in Postsynaptic Differentiation PAK4 NRG3 CHRM1 CHRNA1 DAG1 DMD DVL1 EGFR CTTN NRG1 ITGA1 ITGB1 JUN LAMA2 LAMA3 LAMA4 MUSK PAK1 PAK2 PAK3 MAPK1 MAPK3 MAPK8 PAK6 PAK7 PTK2 ACTA1 PXN RAC1 RAPSN SP1 SRC UTRN NRG2 GIT2 CDC42
akap95Pathway AKAP95 role in mitosis and chromosome dynamics AKAP8 DDX5 PPP1CA PPP2CA PRKACB PRKACG PRKAG1 PRKAR2A PRKAR2B CCNB1 CDC2 NCAPD2
aktPathway AKT Signaling Pathway CHUK AKT1 FOXO1 FOXO3 GH1 GHR HSP90AA1 IKBKB FASLG FOXO4 NFKB1 NFKBIA PDPK1 PIK3CA PIK3CG PIK3R1 PPP2CA BAD RELA YWHAH CASP9 IKBKG
alkPathway ALK in cardiac myocytes ATF2 NKX2-5 CTNNB1 DVL1 GATA4 BMP10 GSK3B APC SMAD1 SMAD4 SMAD5 SMAD6 MEF2C MYL2 NPPA NPPB RFC1 BMP2 BMP4 BMP5 BMP7 BMPR1A BMPR2 MAP3K7 HNF1A TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 WNT1 AXIN1 FZD1 CHRD ACVR1 NOG
ParkinsonsPathway Alpha-synuclein and Parkin-mediated proteolysis in Parkinson s disease PARK2 SNCA
At1rPathway Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling CYCSP35 ATF2 AGT AGTR1 EGFR ELK1 PTK2B GNAQ GRB2 HRAS JUN MEF2A MEF2B MEF2C MEF2D MAP3K1 PAK1 PRKCA PRKCB MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTK2 RAC1 RAF1 MAP2K4 SHC1 SOS1 SRC CALM1 CALM2 CALM3
ace2Pathway Angiotensin-converting enzyme 2 regulates heart function CMA1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ACE AGT AGTR1 AGTR2 ACE2 REN
asbcellPathway Antigen Dependent B Cell Activation HLA-DRA HLA-DRB1 FAS IL2 FASLG IL4 IL10 CD4 CD28 CD80 CD40 CD40LG
DNAfragmentPathway Apoptotic DNA fragmentation and tissue homeostasis DFFA DFFB ENDOG GZMB HMGB1 HMGB2 TOP2A TOP2B CASP3 CASP7
chemicalPathway Apoptotic Signaling in Response to DNA Damage PARP1 EIF2S1 AKT1 APAF1 ATM CYCS PRKCA PRKCB BAD PTK2 BAX PXN BCL2 BCL2L1 BID STAT1 TLN1 TP53 CASP3 CASP6 CASP7 CASP9
sppaPathway Aspirin Blocks Signaling Pathway Involved in Platelet Activation F2 F2R PLCB1 GNAI1 GNB1 GNGT1 HRAS ITGA1 ITGB1 PLA2G4A PRKCA PRKCB MAPK1 MAPK3 MAP2K1 PTGS1 PTK2 RAF1 SRC SYK TBXAS1 F2RL3
atmPathway ATM Signaling Pathway RAD50 CDKN1A CHEK1 CHEK2 GADD45A ABL1 JUN MDM2 MRE11A NBN ATM NFKB1 NFKBIA MAPK8 RAD51 RBBP8 RELA BRCA1 TP53 TP73
agpcrPathway Attenuation of GPCR Signaling GNAS GNB1 GNGT1 GRK4 ARRB1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB
blymphocytePathway B Lymphocyte Cell Surface Molecules CR1 CR2 FCGR2B HLA-DRA HLA-DRB1 ICAM1 ITGAL ITGB2 PTPRC CD80 CD40
pparPathway Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression PPARA PPARD PPARG RXRA
bcrPathway BCR Signaling Pathway CYCSP35 MAPK14 ELK1 FOS GRB2 BLNK HRAS JUN LYN MAP3K1 NFATC1 NFATC2 NFATC3 NFATC4 PLCG1 PPP3CA PPP3CB PPP3CC PRKCA PRKCB MAPK3 MAPK8 MAP2K1 RAC1 RAF1 SHC1 SOS1 SYK BTK VAV1 CALM1 CALM2 CALM3 CD79A CD79B
biopeptidesPathway Bioactive Peptide Induced Signaling Pathway CDK5 CYCSP35 MAPK14 AGT AGTR2 F2 PTK2B FYN GNA11 GNAI1 GNB1 GNGT1 GRB2 HRAS JAK2 KNG1 MAPT MYLK PLCG1 PRKCA PRKCB MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 RAF1 SHC1 SOS1 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G
botulinPathway Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1 CHRNA1 SNAP25 STX1A VAMP2
ranklPathway Bone Remodelling IRF9 FOS FOSL2 IFNAR1 IFNAR2 IFNB1 NFKB1 MAPK8 EIF2AK2 RELA TRAF6 FOSL1 TNFSF11 TNFRSF11A
bbcellPathway Bystander B Cell Activation HLA-DRA HLA-DRB1 FAS FASLG CD4 CD28 CD40 CD40LG
CaCaMPathway Ca++/ Calmodulin-dependent Protein Kinase Activation CAMKK2 CYCSP35 CREB1 CAMK1G CALM1 CALM2 CALM3 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G CAMKK1 CAMK1
cdMacPathway Cadmium induces DNA synthesis and proliferation in macrophages PLCB1 FOS HRAS JUN MYC NFKB1 NFKBIA CUZD1 PRKCA PRKCB MAPK1 MAPK3 MAP2K1 RAF1 RELA TNF
HBxPathway Calcium Signaling by HBx of Hepatitis B virus HBXIP CREB1 PTK2B GRB2 HRAS SHC1 SOS1 SRC
flumazenilPathway Cardiac Protection Against ROS GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GPX1 PRKCE SOD1
caspasePathway Caspase Cascade in Apoptosis PARP1 DFFA DFFB GZMB APAF1 BIRC2 BIRC3 XIAP ARHGDIB LMNA LMNB1 CYCS PRF1 CASP1 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP9 CASP10 LMNB2
argininecPathway Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline GLS GLUD1 ARG1 OAT PRODH ALDH4A1
methioninepathway Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDK CTH MUT BCKDHB CBS
cblPathway CBL mediated ligand-induced downregulation of EGF receptors CSF1R EGF EGFR GRB2 SH3KBP1 MET SH3GLB1 PDGFRA PRKCA PRKCB SH3GLB2 SRC CBL
CCR3Pathway CCR3 signaling in Eosinophils CFL1 CCR3 PLCB1 NOX1 GNAQ GNAS GNB1 GNGT1 HRAS RHOA LIMK1 MYL2 PPP1R12B PIK3C2G PRKCA PRKCB MAPK1 MAPK3 MAP2K1 PTK2 RAF1 CCL11 ROCK2
cd40Pathway CD40L Signaling Pathway CHUK DUSP1 IKBKB MAP3K1 NFKB1 NFKBIA RELA TNFAIP3 TRAF3 TRAF6 IKBKG IKBKAP MAP3K14 CD40 CD40LG
cdc25Pathway cdc25 and chk1 Regulatory Pathway in response to DNA damage CHEK1 MYT1 ATM WEE1 YWHAH CDC2 CDC25A CDC25B CDC25C
mcmPathway CDK Regulation of DNA Replication CDK2 CDKN1B ORC6L ORC3L MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 KITLG ORC1L ORC2L ORC4L ORC5L CDT1 CCNE1 CDC6
g1Pathway Cell Cycle: G1/S Check Point CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B DHFR E2F1 ABL1 GSK3B HDAC1 SMAD3 SMAD4 ATM ATR RB1 CCND1 SKP2 TFDP1 TGFB1 TGFB2 TGFB3 TP53 CCNA1 CCNE1 CDC2 CDC25A
g2Pathway Cell Cycle: G2/M Checkpoint CDKN1A CDKN2D YWHAQ CHEK1 CHEK2 GADD45A EP300 MDM2 MYT1 ATM PLK1 ATR PRKDC RPS6KA1 BRCA1 TP53 WEE1 YWHAH CCNB1 CDC2 CDC25A CDC25B CDC25C CDC34
cell2cellPathway Cell to Cell Adhesion Signaling CSK CTNNA1 CTNNA2 CTNNB1 CTNNA3 PECAM1 PTK2 PXN SRC VCL ACTN1 ACTN2 ACTN3 BCAR1
LairPathway Cells and Molecules involved in local acute inflammatory response ICAM1 IL1A IL6 IL8 ITGA4 ITGAL ITGB1 ITGB2 KNG1 SELP SELPLG TNF C3 C5 C6 C7 VCAM1
ceramidePathway Ceramide Signaling Pathway MAP3K1 NFKB1 CYCS MAPK1 MAPK3 MAPK8 MAP2K1 BAD BAX RAF1 BCL2 RELA MAP2K4 SMPD1 TNFRSF1A TRAF2 CASP8 NSMAF TRADD RIPK1 FADD AIFM1
tidPathway Chaperones modulate interferon Signaling Pathway USH1C TAX1BP3 HSPA1A IFNG IFNGR1 IFNGR2 IKBKB JAK2 NFKB1 NFKBIA RB1 RELA TNF TNFRSF1A TNFRSF1B TP53 WT1 LIN7A DNAJA3
classicPathway Classical Complement Pathway C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C5 C6 C7 C8A C9
compPathway Complement Pathway MASP2 CFD MBL2 MASP1 CFB C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C5 C6 C7 C8A C9
vdrPathway Control of Gene Expression by Vitamin D Receptor CARM1 NCOA2 CREBBP EP300 HDAC1 MED1 RXRA TSC2 NCOA3 NCOA1 KAT2B NCOR1
hdacPathway Control of skeletal myogenesis by HDAC calcium/calmodulin-dependent kinase (CaMK) HDAC5 CYCSP35 MAPK14 AKT1 CABIN1 IGF1 IGF1R INS INSR MEF2A MEF2B MEF2C MEF2D MYOD1 NFATC1 NFATC2 PIK3CA PIK3CG PIK3R1 PPP3CA PPP3CB PPP3CC MAPK7 MAP2K6 CAMK1G YWHAH CALM1 CALM2 CALM3 CAMK1
gcrPathway Corticosteroids and cardioprotection CORIN CYCSP35 ADRB2 AKT1 GNAS GNB1 GNGT1 NR3C1 ANXA1 HSP90AA1 NFKB1 NOS3 NPPA PIK3CA PIK3CG PIK3R1 RELA CALM1 CALM2 CALM3
ctcfPathway CTCF: First Multivalent Nuclear Factor CDKN1B CDKN2A FRAP1 SMAD1 SMAD4 SMAD5 MDM2 MYC PIK3CA PIK3CG PIK3R1 PPP2CA PTEN RPS6KB1 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TP53 CD79A CD79B
ctlPathway CTL mediated immune response against target cells GZMB HLA-A ICAM1 FAS FASLG ITGAL ITGB2 PRF1 B2M TRA@ TRB@ CD3D CD3E CD3G CD247
cxcr4Pathway CXCR4 Signaling Pathway CRK PTK2B GNAI1 GNAQ GNB1 GNGT1 HRAS NFKB1 PIK3C2G PIK3CA PIK3R1 PLCG1 PRKCA PRKCB MAPK1 MAPK3 MAP2K1 PTK2 PXN RAF1 RELA CXCL12 CXCR4 BCAR1
fbw7Pathway Cyclin E Destruction Pathway CDK2 E2F1 FBXW7 RB1 SKP1 TFDP1 CUL1 CCNE1 CDC34
ranPathway Cycling of Ran in nucleocytoplasmic transport RCC1 RAN RANBP1 RANBP2 RANGAP1
cellcyclePathway Cyclins and Cell Cycle Regulation CDK2 CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D E2F1 RB1 RBL1 CCND1 TFDP1 CCNA1 CCNB1 CCND2 CCND3 CCNE1 CCNH CDC2 CDC25A
cytokinePathway Cytokine Network IFNA1 IFNB1 IFNG IL1A IL2 IL3 IL4 IL5 IL6 IL8 IL9 IL10 IL12A IL12B IL13 IL15 IL16 IL17A IL18 LTA TNF
inflamPathway Cytokines and Inflammatory Response CSF1 CSF2 CSF3 HLA-DRA HLA-DRB1 IFNA1 IFNB1 IFNG IL1A IL2 IL3 IL4 IL5 IL6 IL7 IL8 IL10 IL11 IL12A IL12B IL13 IL15 LTA PDGFA TGFB1 TGFB2 TGFB3 TNF CD4
d4gdiPathway D4-GDI Signaling Pathway PARP1 GZMB APAF1 JUN ARHGAP5 ARHGDIB CYCS PRF1 CASP1 CASP3 CASP8 CASP9 CASP10
dcPathway Dendritic cells in regulating TH1 and TH2 Development CSF2 ANPEP IFNA1 IFNB1 IFNG IL3 IL4 IL5 IL10 IL12A IL12B IL13 ITGAX TLR7 TLR9 TLR2 TLR4 CD2 CD5 CD7 CD33 CD40
p35alzheimersPathway Deregulation of CDK5 in Alzheimers Disease CDK5 CSNK1A1 CSNK1D GSK3B APP MAPT PPP2CA CAPN1 CAPNS1 CAPNS2 CDK5R1
rnaPathway Double Stranded RNA Induced Gene Expression CHUK EIF2S1 NFKB1 NFKBIA EIF2AK2 DNAJC3 RELA TP53 EIF2S2 MAP3K14
mta3Pathway Downregulated of MTA-3 in ER-negative Breast Tumors CTSD ESR1 ALDOA GAPDH HDAC1 HSPB1 HSPB2 PDZK1 MBD3 MTA3 SNAI2 SNAI1 TUBA4A TUBA3C TUBA1A TUBA4B TUBA1C MTA1 CDH1
skp2e2fPathway E2F1 Destruction Pathway CDK2 E2F1 RB1 SKP1 SKP2 TFDP1 CUL1 CCNA1 CCNE1 CDC34
calcineurinPathway Effects of calcineurin in Keratinocyte Differentiation CDKN1A CYCSP35 GNAQ MARCKS NFATC1 NFATC2 NFATC3 NFATC4 PLCG1 PPP3CA PPP3CB PPP3CC PRKCA PRKCB SP1 SP3 CALM1 CALM2 CALM3
egfPathway EGF Signaling Pathway CSNK2A1 EGF EGFR ELK1 FOS GRB2 HRAS JAK1 JUN MAP3K1 PIK3CA PIK3R1 PLCG1 PRKCA PRKCB MAPK3 MAPK8 MAP2K1 RAF1 RASA1 MAP2K4 SHC1 SOS1 SRF STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6
etcPathway Electron Transport Reaction in Mitochondria GPD2 SLC25A4 SLC25A6 COX1 NDUFA1 ATP5A1 CYCS SDHA SDHB SDHC SDHD UQCRC1
ndkDynaminPathway Endocytotic role of NDK, Phosphins and Dynamin AP2M1 CYCSP35 AP2A1 DNM1 EPS15 AMPH BIN1 EPN1 NME1 NME2 PPP3CA PPP3CB PPP3CC CALM1 CALM2 CALM3 PICALM SYNJ1 SYNJ2
ephA4Pathway Eph Kinases and ephrins support platelet aggregation EPHA4 EPHB1 FYN ITGA1 ITGB1 L1CAM LYN ACTA1 RAP1B SELP
epoPathway EPO Signaling Pathway CSNK2A1 ELK1 EPO EPOR FOS GRB2 HRAS JAK2 JUN PLCG1 MAPK3 MAPK8 MAP2K1 PTPN6 RAF1 SHC1 SOS1 STAT5A STAT5B
ecmPathway Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia DIAPH1 FYN GSN HRAS ITGA1 ITGB1 RHOA ARHGAP5 MYL2 MYLK PFN1 PIK3CA PIK3CG PIK3R1 MAPK1 MAPK3 MAP2K1 PTK2 PXN RAF1 ROCK1 SHC1 SRC TLN1
erkPathway Erk1/Erk2 Mapk Signaling pathway EGFR ELK1 GNAS GNB1 GNGT1 MKNK2 GRB2 HRAS IGF1R ITGB1 MYC NGF NGFR PDGFRA PPP2CA MAPK1 MAPK3 MAP2K1 MAP2K2 PTPRR RAF1 RPS6KA1 SHC1 SOS1 SRC STAT3 MKNK1 RPS6KA5
erythPathway Erythrocyte Differentiation Pathway CSF2 CSF3 EPO FLT3 IGF1 IL1A IL3 IL6 IL9 IL11 KITLG CCL3 TGFB1 TGFB2 TGFB3
eponfkbPathway Erythropoietin mediated neuroprotection through NF-kB CDKN1A EPO EPOR GRIN1 HIF1A JAK2 ARNT NFKB1 NFKBIA RELA SOD2
EfpPathway Estrogen-responsive protein Efp controls cell cycle and breast tumors growth ESR1 TP53
eifPathway Eukaryotic protein translation EIF1 EEF2 EIF1AX EIF2S1 EIF2S3 EIF4A1 EIF4A2 EIF4E EIF4G1 EIF4G2 EIF5 EEF2K EIF6 EIF3A EIF4G3 EIF2S2
extrinsicPathway Extrinsic Prothrombin Activation Pathway F2 F2R F3 F5 F7 F10 FGA FGB FGG SERPINC1 PROC PROS1 TFPI
fasPathway FAS signaling pathway ( CD95 ) FAF1 PARP1 DAXX DFFA DFFB FAS FASLG JUN ARHGDIB LMNA LMNB1 MAP3K1 PAK1 PAK2 PRKDC MAPK8 PTPN13 RB1 MAP2K4 SPTAN1 MAP3K7 CASP3 CASP6 CASP7 CASP8 CASP10 LMNB2 RIPK2 FADD CFLAR
fcer1Pathway Fc Epsilon Receptor I Signaling in Mast Cells CYCSP35 ELK1 FCER1A FCER1G FOS GRB2 HRAS JUN LYN MAP3K1 NFATC1 NFATC2 NFATC3 NFATC4 PAK2 PIK3CA PIK3CG PIK3R1 PLA2G4A PLCG1 PPP3CA PPP3CB PPP3CC PRKCB MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K7 RAF1 MAP2K4 SHC1 SOS1 SYK BTK VAV1 CALM1 CALM2 CALM3
fibrinolysisPathway Fibrinolysis Pathway CPB2 F2 F2R F13A1 FGA FGB FGG SERPINE1 SERPINB2 PLAT PLAU PLG
fMLPpathway fMLP induced chemokine gene expression in HMC-1 cells CYCSP35 MAPK14 ELK1 PLCB1 FPR1 GNA15 GNB1 GNGT1 HRAS MAP3K1 NCF2 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA PAK1 PIK3C2G PPP3CA PPP3CB PPP3CC MAPK1 MAPK3 MAP2K1 MAP2K2 MAP2K3 MAP2K6 CAMK1G RAC1 RAF1 RELA NCF1C CALM1 CALM2 CALM3 CAMK1
freePathway Free Radical Induced Apoptosis NOX1 GPX1 GSR GSS IL8 NFKB1 RELA SOD1 TNF XDH
fxrPathway FXR and LXR Regulation of Cholesterol Metabolism NR1H3 ABCA1 FABP6 LDLR RXRA NR0B2 NR1H4
gabaPathway Gamma-aminobutyric Acid Receptor Life Cycle GPHN GABARAP DNM1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 SRC
GATA3pathway GATA3 participate in activating the Th2 cytokine genes expression MAPK14 GATA3 IL4 IL5 IL13 JUNB MAF NFATC1 NFATC2 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B MAP2K3
ghrelinPathway Ghrelin: Regulation of Food Intake and Energy Homeostasis GH1 IGF1 IGFBP3
glycolysisPathway Glycolysis Pathway ENO1 ALDOB GAPDH GPI HK1 PFKL PGAM1 PGK1 PKLR TPI1
tubbyPathway G-Protein Signaling Through Tubby Proteins CHRM1 PLCB1 GNAQ GNB1 GNGT1 HTR2C TUB
setPathway Granzyme A mediated Apoptosis Pathway CREBBP DFFA DFFB GZMA GZMB HMGB2 APEX1 NME1 PRF1 SET ANP32A
ghPathway Growth Hormone Signaling Pathway GH1 GHR GRB2 HRAS INS INSR IRS1 JAK2 PIK3CA PIK3CG PIK3R1 PLCG1 PRKCA PRKCB MAPK1 MAPK3 MAP2K1 PTPN6 RAF1 RPS6KA1 SHC1 SLC2A4 SOS1 SRF STAT5A STAT5B HNF1A SOCS1
erbB4pathway g-Secretase mediated ErbB4 Signaling Pathway NRG3 ERBB4 PRKCA PRKCB PSEN1 ADAM17 NRG2
ahspPathway Hemoglobin s Chaperone CPOX ALAD ALAS1 ALAS2 FECH GATA1 HBA1 HBA2 HBB HMBS ERAF UROD UROS
tcapoptosisPathway HIV Induced T Cell Apoptosis CCR5 FAS FASLG TRA@ TRB@ CD3D CD3E CD3G CD247 CD4 CD28
HivnefPathway HIV-I Nef: negative effector of Fas and TNF CHUK PARP1 DAXX DFFA DFFB GSN APAF1 BIRC2 BIRC3 XIAP FAS FASLG ARHGDIB LMNA LMNB1 MDM2 MAP3K1 MAP3K5 NFKB1 NFKBIA NUMA1 PAK2 CYCS PRKCD PRKDC MAPK8 MAP2K7 PSEN1 PSEN2 PTK2 RASA1 RB1 BCL2 RELA BID SPTAN1 ACTG1 TNF TNFRSF1A TNFRSF1B TRAF1 TRAF2 CDC2L2 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 LMNB2 TRADD RIPK1 CRADD FADD CFLAR MAP3K14 BAG4 CDC2L1
salmonellaPathway How does salmonella hijack a cell ARPC5 ARPC4 ARPC3 ARPC1B ACTR3 ACTR2 ARPC2 ARPC1A ACTA1 RAC1 WASF1 WASL CDC42
mPRPathway How Progesterone Initiates Oocyte Membrane ARPC5 ARPC4 ARPC3 ARPC1B ACTR3 ACTR2 ARPC2 CAP1 ARPC1A ADCY1 PAQR7 GNAI1 GNAS GNB1 GNGT1 HRAS MYT1 PGR PIN1 PAQR5 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B MAPK1 MAPK3 ACTA1 RPS6KA1 SRC CCNB1 CDC2 CDC25C
hcmvPathway Human Cytomegalovirus and Map Kinase Pathways CREB1 MAPK14 AKT1 MAP3K1 NFKB1 PIK3CA PIK3CG PIK3R1 MAPK1 MAPK3 MAP2K1 MAP2K2 MAP2K3 MAP2K6 RB1 RELA SP1
p53hypoxiaPathway Hypoxia and p53 in the Cardiovascular system CDKN1A CSNK1A1 CSNK1D GADD45A DNAJB1P NQO1 EP300 AKT1 FHL2 HIC1 HIF1A HSPA1A HSP90AA1 IGFBP3 MDM2 ATM NFKBIB ABCB1 MAPK8 BAX RPA1 TAF1 TP53
hifPathway Hypoxia-Inducible Factor in the Cardiovascular System COPS5 CREB1 EDN1 EP300 EPO HIF1A HSP90AA1 JUN LDHA ARNT ASPH NOS3 P4HB VEGFA VHL
ifnaPathway IFN alpha signaling pathway IRF9 IFNA1 IFNAR1 IFNAR2 IFNB1 JAK1 STAT1 STAT2 TYK2
igf1Pathway IGF-1 Signaling Pathway CSNK2A1 ELK1 FOS GRB2 HRAS IGF1 IGF1R IRS1 JUN PIK3CA PIK3CG PIK3R1 MAPK3 MAPK8 MAP2K1 PTPN11 RAF1 RASA1 SHC1 SOS1 SRF
il17Pathway IL 17 Signaling Pathway CSF3 IL3 IL6 IL8 IL17A KITLG TRA@ TRB@ CD2 CD3D CD3E CD3G CD247 CD4 CD8A CD34 CD58
il2Pathway IL 2 signaling pathway CSNK2A1 ELK1 FOS GRB2 HRAS IL2 IL2RA IL2RB IL2RG JAK1 JAK3 JUN LCK MAPK3 MAPK8 MAP2K1 RAF1 SHC1 SOS1 STAT5A STAT5B SYK
il3Pathway IL 3 signaling pathway CSF2RB FOS GRB2 HRAS IL3 IL3RA JAK2 MAPK3 MAP2K1 PTPN6 RAF1 SHC1 SOS1 STAT5A STAT5B
il4Pathway IL 4 signaling pathway AKT1 GRB2 IL2RG IL4 IL4R IRS1 JAK1 JAK3 RPS6KB1 SHC1 STAT6
il5Pathway IL 5 Signaling Pathway CCR3 HLA-DRA HLA-DRB1 IL1B IL4 IL5 IL5RA IL6 CCL11 CD4
il6Pathway IL 6 signaling pathway CEBPB CSNK2A1 ELK1 FOS GRB2 HRAS IL6 IL6R IL6ST JAK1 JAK2 JAK3 JUN MAPK3 MAP2K1 PTPN11 RAF1 SHC1 SOS1 SRF STAT3 TYK2
il10Pathway IL-10 Anti-inflammatory Signaling Pathway HMOX1 IL1A IL6 IL10 IL10RA IL10RB JAK1 BLVRA BLVRB STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TNF
IL12Pathway IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5 MAPK14 ETV5 CXCR3 IFNG IL12A IL12B IL12RB1 IL12RB2 IL18 JAK2 JUN MAPK8 MAP2K6 STAT4 TRA@ TRB@ TYK2 IL18R1 CD3D CD3E CD3G CD247
il2rbPathway IL-2 Receptor Beta Chain in T cell Activation CRKL E2F1 AKT1 IKZF3 FOS GRB2 HRAS FAS IL2RA FASLG IL2RB IL2RG IRS1 JAK1 JAK3 MYC PIK3CA PIK3CG PIK3R1 PPIA MAPK1 MAPK3 BAD PTPN6 RAF1 BCL2 BCL2L1 RPS6KB1 SHC1 SOS1 STAT5A STAT5B SYK SOCS1 CBL CFLAR SOCS3 NMI
il22bppathway IL22 Soluble Receptor Signaling Pathway IL22RA2 IL10RA JAK1 JAK2 JAK3 IL22 IL22RA1 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TYK2 SOCS3
il7Pathway IL-7 Signal Transduction CREBBP EP300 PTK2B FYN IL2RG IL7 IL7R JAK1 JAK3 LCK PIK3CA PIK3CG PIK3R1 BCL2 STAT5A STAT5B NMI
gsk3Pathway Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages TIRAP CTNNB1 DVL1 AKT1 LY96 GJA1 GNAI1 GSK3B APC IRAK1 LBP MYD88 NFKB1 LEF1 PDPK1 PIK3CA PIK3R1 TOLLIP PPP2CA EIF2AK2 CCND1 RELA TLR4 WNT1 AXIN1 FZD1 CD14
deathPathway Induction of apoptosis through DR3 and DR4/5 Death Receptors CHUK DFFA DFFB GAS2 APAF1 BIRC2 BIRC3 XIAP LMNA NFKB1 NFKBIA CYCS BCL2 RELA BID SPTAN1 TRAF2 CASP3 CASP6 CASP7 CASP8 CASP9 CASP10 TRADD TNFRSF25 RIPK1 TNFSF12 TNFSF10 FADD TNFRSF10B TNFRSF10A CFLAR MAP3K14
RacCycDPathway Influence of Ras and Rho proteins on G1 to S Transition CDK2 CDK4 CDK6 CDKN1A CDKN1B CHUK E2F1 AKT1 HRAS IKBKB RHOA NFKB1 NFKBIA PAK1 PIK3CA PIK3R1 MAPK1 MAPK3 RAC1 RAF1 RB1 CCND1 RELA TFDP1 IKBKG CCNE1
gleevecpathway Inhibition of Cellular Proliferation by Gleevec CRKL AKT1 FOS GRB2 HRAS JAK2 JUN MAP3K1 MYC PIK3CA PIK3CG PIK3R1 MAPK3 MAPK8 MAP2K1 BAD RAF1 BCR MAP2K4 SOS1 STAT1 STAT5A STAT5B
HuntingtonPathway Inhibition of Huntington s disease neurodegeneration by histone deacetylase inhibitors CREB1 CREBBP HTT HDAC1
reckPathway Inhibition of Matrix Metalloproteinases HRAS MMP2 MMP9 MMP14 TIMP1 TIMP2 TIMP3 TIMP4 RECK
insulinPathway Insulin Signaling Pathway CSNK2A1 ELK1 FOS GRB2 HRAS INS INSR IRS1 JUN PIK3CA PIK3CG PIK3R1 MAPK3 MAPK8 MAP2K1 PTPN11 RAF1 RASA1 SHC1 SLC2A4 SOS1 SRF
integrinPathway Integrin Signaling Pathway CRKL CSK FYN GRB2 RAPGEF1 HRAS ITGA1 ITGB1 JUN RHOA PPP1R12B MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTK2 ACTA1 PXN RAF1 RAP1A ROCK1 BCR SHC1 SOS1 SRC TLN1 TNS1 VCL ZYX CAPN1 CAPNS1 CAPNS2 CAV1 ACTN1 ACTN2 ACTN3 BCAR1
iresPathway Internal Ribosome Entry Pathway EIF4A1 EIF4A2 EIF4E EIF4G1 EIF4G2 EIF3A EIF4G3
intrinsicPathway Intrinsic Prothrombin Activation Pathway COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F2 F2R F5 F8 F9 F10 F11 F12 FGA FGB FGG KLKB1 KNG1 SERPINC1 PROC PROS1 SERPING1
ionPathway Ion Channel and Phorbal Esters Signaling Pathway PTK2B P2RY2 PLCG1 PRKCA PRKCB
raccPathway Ion Channels and Their Functional Role in Vascular Endothelium ADCY1 GNAS GNB1 GNGT1 NOS3 PRKG1 PRKG2
keratinocytePathway Keratinocyte Differentiation CEBPA CHUK MAPK14 DAXX EGF EGFR ETS1 ETS2 FOS HOXA7 HRAS FAS IKBKB FASLG JUN MAP3K1 MAP3K5 NFKB1 NFKBIA PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ MAPK1 MAPK3 MAPK8 MAPK13 MAP2K1 MAP2K3 MAP2K6 MAP2K7 RAF1 BCL2 RELA MAP2K4 SP1 TNF TNFRSF1A TNFRSF1B TRAF2 RIPK1 MAP3K14
tcraPathway Lck and Fyn tyrosine kinases in initiation of TCR Activation FYN HLA-DRA HLA-DRB1 LCK PTPRC TRA@ TRB@ ZAP70 CD3D CD3E CD3G CD247 CD4
lectinPathway Lectin Induced Complement Pathway MASP2 MBL2 MASP1 C2 C3 C4A C4B C5 C6 C7 C8A C9
pyk2Pathway Links between Pyk2 and Map Kinases CYCSP35 CRKL MAPK14 PTK2B GNAQ GRB2 HRAS JUN MAP3K1 PAK1 PLCG1 PRKCA PRKCB MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 MAP2K3 RAC1 RAF1 MAP2K4 SHC1 SOS1 SRC CALM1 CALM2 CALM3 BCAR1
Lis1Pathway Lissencephaly gene (LIS1) in neuronal migration and development CDK5 CSNK2A1 ABL1 RELN LRP8 CDK5R1
LDLpathway Low-density lipoprotein (LDL) pathway during atherogenesis CSF1 IL6 ACAT1 LDLR LPL CCL2
egfr_smrtePathway Map Kinase Inactivation of SMRT Corepressor MAPK14 EGF EGFR MAP3K1 MAP2K1 RARA RXRA THRA THRB ZBTB16 NCOR2
mapkPathway MAPKinase Signaling Pathway CEBPA MAP3K2 MAP4K5 MAP4K1 CHUK MAP3K8 CREB1 ATF2 MAPK14 DAXX ELK1 FOS MKNK2 GRB2 HRAS IKBKB ARAF JUN MAX MEF2A MEF2B MEF2C MEF2D MAP3K1 MAP3K3 MAP3K4 MAP3K5 MAP3K9 MAP3K10 MAP3K11 MYC NFKB1 NFKBIA PAK1 PAK2 MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK11 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MAP2K6 MAP2K7 MAP4K2 RAC1 RAF1 RELA RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KB2 MAPK12 MAP2K4 SHC1 SP1 BRAF STAT1 MAP3K7 TGFB1 TGFB2 TGFB3 TGFBR1 TRAF2 MAP3K12 MAPKAPK3 MAP4K3 MAPKAPK5 MKNK1 TRADD RIPK1 RPS6KA4 MAP3K14 MAP3K6 MAP3K13 RPS6KA5 MAPKAPK2 MAP4K4 RAPGEF2
mCalpainPathway mCalpain and friends in Cell motility EGF EGFR CXCR3 HRAS ITGA1 ITGB1 MYL2 MYLK PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B MAPK1 MAPK3 PTK2 ACTA1 PXN TLN1 EZR CAPN1 CAPN2 CAPNS1 CAPNS2
AcetaminophenPathway Mechanism of Acetaminophen Activity and Toxicity CYP1A2 CYP2E1 CYP3A IDDM11 PTGS1 PTGS2 NR1I3
pparaPathway Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) SRA1 NR1H3 CITED2 PPARGC1A CPT1B CREBBP DUSP1 DUT EHHADH EP300 FABP1 FAT FRA8B HSD17B4 HSPA1A HSP90AA1 APOA1 APOA2 INS JUN LPL ME1 MYC NFKBIA NOS2 ACOX1 PDGFA PIK3CA PIK3CG PIK3R1 PPARA MED1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB MAPK1 MAPK3 PTGS2 RB1 RELA RXRA MRPL11 SP1 STAT5A STAT5B NR2F1 TNF NRIP1 NR0B2 NCOA1 CD36 NCOR1 NCOR2
mbdPathway Mechanisms of transcriptional repression by DNA methylation SIN3B SIN3A HDAC1 HDAC2 MBD3
melanocytepathway Melanocyte Development and Pigmentation Pathway CREB1 EP300 KIT KITLG MITF BCL2 RPS6KA1
etsPathway METS affect on Macrophage Differentiation HDAC5 DDX20 CSF1 CSF1R E2F1 E2F4 ETS1 ETS2 ETV3 SIN3B FOS SIN3A HDAC2 HRAS JUN RBL1 RBL2 NCOR2
cptPathway Mitochondrial Carnitine Palmitoyltransferase (CPT) System CPT1A CPT2 ACSS2 SLC25A20
monocytePathway Monocyte and its Surface Molecules ICAM1 ITGA4 ITGAL ITGAM ITGB1 ITGB2 PECAM1 SELE SELL SELP CD44
mTORPathway mTOR Signaling Pathway EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4G2 AKT1 FKBP1A FRAP1 PDK2 PDPK1 PIK3CA PIK3R1 PPP2CA PTEN RPS6 RPS6KB1 TSC1 TSC2 MKNK1 EIF3A EIF4G3
igf1rPathway Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation ADCY1 AKT1 GRB2 HRAS IGF1R IRS1 PIK3CA PIK3R1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B MAPK1 MAPK3 MAP2K1 BAD RAF1 RPS6KA1 SHC1 SOS1 YWHAH
pitx2Pathway Multi-step Regulation of Transcription by Pitx2 CREBBP CTNNB1 DVL1 EP300 GSK3B HDAC1 APC LEF1 PITX2 MED1 WNT1 TRRAP AXIN1 FZD1 LDB1
ngfPathway Nerve growth factor pathway (NGF) CSNK2A1 ELK1 FOS GRB2 HRAS JUN NGF NGFR PIK3CA PIK3CG PIK3R1 PLCG1 MAPK3 MAPK8 MAP2K1 RAF1 SHC1 SOS1
vipPathway Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells CHUK CYCSP35 EGR2 EGR3 GNAQ MAP3K1 MYC NFATC1 NFATC2 NFKB1 NFKBIA PLCG1 PPP3CA PPP3CB PPP3CC PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RELA VIP VIPR2 CALM1 CALM2 CALM3
ErbB3Pathway Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling EGF EGFR ERBB3 NRG1 UBE2D1
neutrophilPathway Neutrophil and Its Surface Molecules ICAM1 ITGAL ITGAM ITGB2 PECAM1 SELE SELL CD44
nfatPathway NFAT and Hypertrophy of the heart (Transcription in the broken heart) CYCSP35 CREBBP MAPK14 CSNK1A1 NKX2-5 CTF1 AGT HBEGF EDN1 AKT1 F2 FGF2 FKBP1A GATA4 GSK3B HRAS IGF1 LIF MEF2C MYH2 NFATC1 NFATC2 NFATC3 NFATC4 NPPA PIK3CA PIK3CG PIK3R1 PPP3CA PPP3CB PPP3CC PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B MAPK1 MAPK3 MAPK8 MAP2K1 CAMK1G ACTA1 RAF1 RPS6KB1 ELSPBP1 CALM1 CALM2 CALM3 CALR CAMK4 CAMK1 HAND1 HAND2
nthiPathway NFkB activation by Nontypeable Hemophilus influenzae CHUK CREBBP MAPK14 DUSP1 EP300 NR3C1 IKBKB IL1B IL8 SMAD3 SMAD4 MYD88 NFKB1 NFKBIA MAPK11 MAP2K3 MAP2K6 RELA MAP3K7 TGFBR1 TGFBR2 TLR2 TNF MAP3K14
nfkbPathway NF-kB Signaling Pathway MAP3K7IP1 CHUK IKBKB IL1A IL1R1 IRAK1 MAP3K1 MYD88 NFKB1 NFKBIA RELA MAP3K7 TLR4 TNF TNFAIP3 TNFRSF1A TNFRSF1B TRAF6 IKBKG TRADD RIPK1 FADD MAP3K14
no2il12Pathway NO2-dependent IL 12 Pathway in NK cells CCR5 CXCR3 IFNG IL12A IL12B IL12RB1 IL12RB2 JAK2 NOS2 STAT4 TYK2 CD2 CD3D CD3E CD3G CD247 CD4
rarrxrPathway Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells NCOA2 ERCC3 GTF2A1 GTF2B GTF2E1 GTF2F1 POLR2A RARA RXRA TBP NCOA3 NCOA1 HDAC3 KAT2B NCOR2
nuclearRsPathway Nuclear Receptors in Lipid Metabolism and Toxicity NR1H3 CYP1A2 CYP2E1 IDDM11 ABCB1 ABCB4 PPARA PPARD PPARG RARA NR0B2 ABCB11 ABCC3 NR1I3 NR1H4
aifPathway Opposing roles of AIF in Apoptosis and Cell Survival PARP1 CYCS BCL2L1 AIFM1
tertpathway Overview of telomerase protein component gene hTert Transcriptional Regulation HDAC1 MAX MYC SP1 SP3 TP53 WT1 MZF1
tercPathway Overview of telomerase RNA component gene hTerc Transcriptional Regulation NFYA NFYB NFYC RB1 SP1 SP3
arenrf2Pathway Oxidative Stress Induced Gene Expression Via Nrf2 CREB1 MAPK14 FOS MAFF JUN MAFG FXYD2 PRKCA PRKCB MAPK1 MAPK8 MAFK KEAP1
p38mapkPathway p38 MAPK Signaling Pathway CREB1 ATF2 MAPK14 DAXX DDIT3 ELK1 GRB2 HMGN1 HRAS HSPB1 HSPB2 MAX MEF2A MEF2B MEF2C MEF2D MAP3K1 MAP3K5 MAP3K9 MYC PLA2G4A MAP2K6 RAC1 MAP2K4 SHC1 STAT1 MAP3K7 TGFB1 TGFB2 TGFB3 TGFBR1 TRAF2 MAPKAPK5 MKNK1 TRADD RIPK1 RPS6KA5 MAPKAPK2 RAPGEF2 CDC42
p53Pathway p53 Signaling Pathway CDK2 CDK4 CDKN1A GADD45A E2F1 APAF1 MDM2 ATM PCNA BAX RB1 CCND1 BCL2 TIMP3 TP53 CCNE1
pdgfPathway PDGF Signaling Pathway CSNK2A1 ELK1 FOS GRB2 HRAS JAK1 JUN MAP3K1 PDGFA PDGFRA PIK3CA PIK3CG PIK3R1 PLCG1 PRKCA PRKCB MAPK3 MAPK8 MAP2K1 RAF1 RASA1 MAP2K4 SHC1 SOS1 SRF STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6
pelp1Pathway Pelp1 Modulation of Estrogen Receptor Activity CREBBP EP300 ESR1 PELP1 MAPK1 MAPK3 SRC
Ccr5Pathway Pertussis toxin-insensitive CCR5 Signaling in Macrophage CYCSP35 CCR5 MAPK14 PTK2B FOS GNAQ JUN PLCG1 PRKCA PRKCB MAPK8 CCL2 CCL4 CXCL12 CXCR4 CALM1 CALM2 CALM3
ptdinsPathway Phosphoinositides and their downstream targets. AP2M1 AP2A1 JAG1 AKT1 GSK3A GSK3B ARF1 LYN PDPK1 PFKL PFKM PFKP PLCG1 PRKCE PRKCZ BAD RAB5A RAC1 RPS6KB1 BTK VAV2 EEA1 ARHGEF2
plcdPathway Phospholipase C d1 in phospholipid associated cell signaling ADRA1B PLCD1 PRKCA PRKCB TGM2
plcPathway Phospholipase C Signaling Pathway AKT1 PLCB1 PIK3CA PIK3CG PIK3R1 PLCG1 PRKCA PRKCB VAV1
plcePathway Phospholipase C-epsilon pathway ADCY1 ADRB2 GNAS PLCE1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTGER1 RAP2B
edg1Pathway Phospholipids as signalling intermediaries ADCY1 S1PR1 AKT1 PLCB1 GNAI1 GNB1 GNGT1 ITGAV ITGB3 RHOA ASAH1 PDGFA PDGFRA PIK3CA PIK3CG PIK3R1 PRKCA PRKCB MAPK1 MAPK3 PTK2 RAC1 SMPD1 SMPD2 SRC SPHKAP SPHK1
cdk5Pathway Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway CDK5 EGR1 HRAS NGF NGFR MAPK1 MAPK3 MAP2K1 MAP2K2 RAF1 CDK5R1
myosinPathway PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase GNA13 ARHGEF19 ARHGEF15 ARHGEF9 PLCB1 ARHGEF12 ARHGEF18 ARHGEF16 GNA12 GNAQ GNB1 GNGT1 ARHGAP5 MYL2 MYLK PPP1R12B ARHGEF4 ARHGEF3 PRKCA PRKCB PKN1 MYL7 ROCK1 ARHGEF5 ARHGEF7 ARHGEF1 ARHGEF2 ARHGEF6 ARHGEF10 ARHGEF11 ARHGEF17
plateletAppPathway Platelet Amyloid Precursor Protein Pathway COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F2 F9 F11 APP SERPINE1 PLAT PLAU PLG
ps1Pathway Presenilin action in Notch and Wnt signaling CTNNB1 DVL1 DLL1 GSK3B APC RBPJ NOTCH1 PSEN1 ADAM17 HNF1A WNT1 AXIN1 FZD1 BTRC
pepiPathway Proepithelin Conversion to Epithelin and Wound Repair Control ELA1 ELA2 ELA3B GRN IL8 RP11-265F14.2 ELA2A SLPI
akapCentrosomePathway Protein Kinase A at the Centrosome AKAP9 RHOA MAP2 PCNT PPP1CA PPP2CA PRKACB PRKACG PRKAG1 PRKAR2A PRKAR2B PRKCE PKN1 NUP85 CDC2
notchpathway Proteolysis and Signaling Pathway of Notch DLL1 RBPJ NOTCH1 FURIN PSEN1 ADAM17
ptenPathway PTEN dependent cell cycle arrest and apoptosis CDKN1B AKT1 FOXO3 GRB2 FASLG ILK ITGB1 PDK2 PDPK1 PIK3CA PIK3R1 MAPK1 MAPK3 PTEN PTK2 SHC1 SOS1 BCAR1
rabPathway Rab GTPases Mark Targets In The Endocytotic Machinery RAB8A ACTA1 RAB1A RAB2A RAB3A RAB4A RAB5A RAB6A RAB27A RAB7A RAB11A RAB9A
rac1Pathway Rac 1 cell motility signaling pathway CDK5 CFL1 RALBP1 CHN1 ARFIP2 LIMK1 MAP3K1 MYL2 MYLK PPP1R12B NCF2 PAK1 PDGFRA PIK3CA PIK3CG PIK3R1 PLD1 RAC1 RPS6KB1 TRIO VAV1 CDK5R1 WASF1
rasPathway Ras Signaling Pathway RALBP1 CHUK ELK1 AKT1 HRAS RHOA FOXO4 NFKB1 PIK3CA PIK3CG PIK3R1 PLD1 MAPK3 MAP2K1 BAD RAC1 RAF1 RALA RALGDS RELA BCL2L1 CASP9 CDC42
nkcellsPathway Ras-Independent pathway in NK cell-mediated cytotoxicity PTK2B LAT HLA-A IL18 ITGB1 KLRC1 KLRC2 KLRC3 KLRD1 PAK1 PIK3CA PIK3R1 MAPK3 MAP2K1 B2M PTPN6 RAC1 SYK VAV1 KLRC4
rbPathway RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage CDK2 CDK4 CHEK1 MAPK14 MYT1 ATM RB1 TP53 WEE1 YWHAH CDC2 CDC25B CDC25C
badPathway Regulation of BAD phosphorylation ADCY1 CSF2RB AKT1 IGF1 IGF1R IL3 IL3RA KIT KITLG PIK3CA PIK3CG PIK3R1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B MAPK1 MAPK3 BAD BAX BCL2 BCL2L1 RPS6KA1 YWHAH
plk3Pathway Regulation of cell cycle progression by Plk3 CHEK1 CHEK2 PLK3 ATM ATR TP53 YWHAH CDC25C
ck1Pathway Regulation of ck1/cdk5 by type 1 glutamate receptors CDK5 CSNK1D DRD1 DRD2 PLCB1 GRM1 PPP1CA PPP2CA PPP3CA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PPP1R1B CDK5R1
eif2Pathway Regulation of eIF2 EIF2S1 EIF2S3 EIF5 EIF2AK1 GSK3B EIF2AK4 PPP1CA EIF2AK2 EIF2B5 EIF2S2 EIF2AK3
eif4Pathway Regulation of eIF4e and p70 S6 Kinase MAPK14 EIF4A1 EIF4A2 EIF4E EIF4EBP1 EIF4G1 EIF4G2 AKT1 FRAP1 GHR PABPC1 IRS1 PDK2 PDPK1 PIK3CA PIK3R1 PRKCA PRKCB MAPK1 MAPK3 PTEN RPS6KB1 MKNK1 EIF4G3
stemPathway Regulation of hematopoiesis by cytokines CSF1 CSF2 CSF3 EPO IL2 IL3 IL4 IL5 IL6 IL7 IL8 IL9 IL11 CD4 CD8A
dspPathway Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases MAPK14 DUSP1 MAPK3 MAPK8
p27Pathway Regulation of p27 Phosphorylation during Cell Cycle Progression CDK2 CDKN1B CKS1B E2F1 NEDD8 RB1 SKP1 SKP2 TFDP1 CUL1 CCNE1 UBE2M RBX1
pgc1aPathway Regulation of PGC-1a HDAC5 PPARGC1A CYCSP35 ESRRA MEF2A MEF2B MEF2C MEF2D PPARA PPP3CA PPP3CB PPP3CC CAMK1G SLC2A4 YWHAH CALM1 CALM2 CALM3 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G CAMK1
pmlPathway Regulation of transcriptional activity by PML CREBBP DAXX SIRT1 HRAS FAS FASLG PAX3 PML RARA RB1 SP100 TNF TNFRSF1A TNFRSF1B TP53 SUMO1 PRAM1
npp1Pathway Regulators of Bone Mineralization COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6
dreampathway Repression of Pain Sensation by the Transcriptional Regulator DREAM CREB1 CREM FOS KCNIP3 JUN OPRK1 POLR2A PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B MAPK3
leptinPathway Reversal of Insulin Resistance by Leptin CPT1A ACACA LEP LEPR PRKAG2 PRKAG3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1
rhoPathway Rho cell motility signaling pathway ARPC5 ARPC4 ARPC3 ARPC1B ACTR3 ACTR2 ARPC2 BAIAP2 ARPC1A CFL1 DIAPH1 GSN RHOA ARHGAP1 ARHGAP4 ARHGAP5 ARHGAP6 LIMK1 MYL2 MYLK PPP1R12B OPHN1 PFN1 ROCK1 SRC TLN1 VCL ARHGEF5 PIP5K1A PIP5K1B ARHGEF1 ARHGEF11
akap13Pathway Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation GNA13 AKAP13 LPAR1 LPAR3 GNA12 RHOA PRKACB PRKACG PRKAG1 PRKAR2A PRKAR2B LPAR2
RNApol3Pathway RNA polymerase III transcription BRF1 GTF3C1 SSB TBP GTF3C5 GTF3C4 GTF3C3
atrbrcaPathway Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility RAD50 CHEK1 CHEK2 TREX1 FANCC FANCD2 FANCE FANCF FANCG HUS1 MRE11A NBN ATM ATR RAD1 RAD9A RAD17 RAD51 BRCA1 BRCA2 TP53
cardiacegfPathway Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy AGT AGTR1 EDN1 EDNRA EDNRB EGF EGFR FOS HRAS JUN RHOA MYC NFKB1 PLCG1 PRKCA PRKCB RELA ADAM12
her2Pathway Role of ERBB2 in Signal Transduction and Oncology CARM1 EGFR EP300 ERBB3 ERBB4 ESR1 GRIP1 GRB2 HRAS IL6 IL6R IL6ST PIK3CA PIK3CG PIK3R1 MAPK1 MAPK3 MAP2K1 RAF1 SHC1 SOS1 STAT3
erk5Pathway Role of Erk5 in Neuronal Survival CREB1 AKT1 GRB2 HRAS MEF2A MEF2B MEF2C MEF2D NTRK1 PIK3CA PIK3CG PIK3R1 PLCG1 MAPK1 MAPK3 MAPK7 RPS6KA1 SHC1
malPathway Role of MAL in Rho-Mediated Activation of SRF DIAPH1 HRAS RHOA LIMK1 MAL MAP3K1 MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 ACTA1 MAP4K2 RAC1 RAF1 ROCK1 SRF HNF1A CDC42
mef2dPathway Role of MEF2D in T-cell Apoptosis CYCSP35 EP300 CABIN1 HDAC1 HDAC2 MEF2D NFATC1 NFATC2 PPP3CA PPP3CB PPP3CC PRKCA PRKCB TRA@ TRB@ CALM1 CALM2 CALM3 CAPN2 CAPNS1 CAPNS2
mitochondriaPathway Role of Mitochondria in Apoptotic Signaling DFFA DFFB ENDOG APAF1 BIRC2 BIRC3 XIAP CYCS DIABLO BAK1 BAX BCL2 BCL2L1 BID BIK CASP3 CASP6 CASP7 CASP8 CASP9 AIFM1
achPathway Role of nicotinic acetylcholine receptors in the regulation of apoptosis CHRNB1 CHRNG AKT1 PTK2B FOXO3 FASLG MUSK PIK3CA PIK3CG PIK3R1 BAD PTK2 RAPSN SRC TERT YWHAH
parkinPathway Role of Parkin in the Ubiquitin-Proteasomal Pathway UBE2F GPR37 PARK2 SEPT5 SNCA UBE2E2 UBE2G1 UBE2G2 UBE2L3 SUMO1 UBE2L6 SNCAIP
cdc42racPathway Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration ARPC5 ARPC4 ARPC3 ARPC1B ACTR3 ACTR2 ARPC2 ARPC1A RHOA PAK1 PDGFRA PIK3CA PIK3R1 RAC1 WASL CDC42
ppargPathway Role of PPAR-gamma Coactivators in Obesity and Thermogenesis NCOA2 PPARGC1A CREBBP EP300 LPL PPARG MED1 RXRA NCOA1
ranMSpathway Role of Ran in mitotic spindle regulation RCC1 TPX2 KPNB1 KPNA2 NUMA1 KIF15 RAN RANBP1 RANGAP1 AURKA
tob1Pathway Role of Tob in T-cell activation TOB1 TOB2 IFNG IL2 IL2RA IL4 SMAD3 SMAD4 TRA@ TRB@ TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 CD3D CD3E CD3G CD247 CD28
nktPathway Selective expression of chemokine receptors during T-cell polarization CCR1 CCR2 CCR3 CCR4 CCR5 CCR7 CSF2 CXCR3 IFNG IFNGR1 IFNGR2 IL2 IL4 IL4R IL5 IL12A IL12B IL12RB1 IL12RB2 CCL3 CCL4 TGFB1 TGFB2 TGFB3 CXCR4 IL18R1 CD4 CD28 CD40LG
malatexPathway Shuttle for transfer of acetyl groups from mitochondria to the cytosol CS MDH1 ME1 ACLY PC PDHA1 SLC25A1 SLC25A11
MITRPathway Signal Dependent Regulation of Myogenesis by Corepressor MITR MEF2A MEF2B MEF2C MEF2D MYOD1 CAMK1G YWHAH CAMK1 HDAC9
il1rPathway Signal transduction through IL1R MAP3K7IP1 IRAK3 CHUK MAPK14 IFNA1 IFNB1 IKBKB IL1A IL1B IL1R1 IL1RAP IL1RN IL6 IRAK1 IRAK2 JUN MAP3K1 MYD88 NFKB1 NFKBIA ECSIT TOLLIP MAPK8 MAP2K3 MAP2K6 RELA MAP3K7 TGFB1 TGFB2 TGFB3 TNF TRAF6 MAP3K14
metPathway Signaling of Hepatocyte Growth Factor Receptor MAP4K1 CRK CRKL DOCK1 ELK1 PTK2B FOS GAB1 GRB2 RAPGEF1 HGF HRAS ITGA1 ITGB1 JUN MET PAK1 PIK3CA PIK3CG PIK3R1 MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTEN PTK2 PTPN11 ACTA1 PXN RAF1 RAP1A RAP1B RASA1 SOS1 SRC STAT3
gpcrPathway Signaling Pathway from G-Protein Families ADCY1 CYCSP35 CREB1 ELK1 FOS GNAI1 GNAQ GNAS GNB1 GNGT1 HRAS JUN NFATC1 NFATC2 NFATC3 NFATC4 PLCG1 PPP3CA PPP3CB PPP3CC PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB MAPK3 MAP2K1 RAF1 RPS6KA3 CALM1 CALM2 CALM3
igf1mtorpathway Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway EIF2S1 EIF2S3 EIF4E EIF4EBP1 AKT1 FRAP1 GSK3B IGF1 IGF1R INPPL1 PDK2 PDPK1 PIK3CA PIK3R1 PPP2CA PTEN RPS6 RPS6KB1 EIF2B5 EIF2S2
slrpPathway Small Leucine-rich Proteoglycan (SLRP) molecules KERA DCN EPYC FMOD LUM BGN
soddPathway SODD/TNFR1 Signaling Pathway BIRC3 TNF TNFRSF1A TNFRSF1B TRAF2 CASP8 TRADD RIPK1 FADD BAG4
shhPathway Sonic Hedgehog (Shh) Pathway DYRK1A GLI1 GLI2 GLI3 GSK3B SUFU PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTCH1 SHH SMO DYRK1B
ptc1Pathway Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle CDK7 MNAT1 PTCH1 SHH XPO1 CCNB1 CCNH CDC2 CDC25A CDC25B CDC25C
spryPathway Sprouty regulation of tyrosine kinase signals SPRY3 SPRY1 SPRY2 EGF EGFR GRB2 HRAS MAPK1 MAPK3 MAP2K1 PTPRB RAF1 RASA1 SHC1 SOS1 SRC SPRY4 CBL
s1pPathway SREBP control of lipid synthesis SCAP HMGCS1 LDLR MBTPS2 SREBF1 SREBF2 MBTPS1
bArrestinPathway b-arrestins in GPCR Desensitization ADCY1 AP2M1 AP2A1 DNM1 PLCB1 GNAS GNB1 GNGT1 ARRB1 PPARA
stathminPathway Stathmin and breast cancer resistance to antimicrotubule agents PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B MAPK13 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G CCNB1 CD2 CD3D CD3E CD3G CD247 CDC2
hsp27Pathway Stress Induction of HSP Regulation DAXX APAF1 HSPB1 HSPB2 FAS IL1A FASLG CYCS ACTA1 BCL2 TNF MAPKAPK3 CASP3 CASP9 MAPKAPK2
ctbp1Pathway SUMOylation as a mechanism to modulate CtBP-dependent gene responses UBA2 SAE1 CTBP1 NOS1 ZEB1 UBE2I SUMO1 CDH1
ranbp2Pathway Sumoylation by RanBP2 Regulates Transcriptional Repression HDAC6 HDAC1 MDM2 RAN RANBP2 RANGAP1 SUMO1 PIAS1 HDAC9
tcrPathway T Cell Receptor Signaling Pathway CYCSP35 ELK1 FOS FYN LAT GRB2 HRAS JUN LCK MAP3K1 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA PIK3CA PIK3CG PIK3R1 PLCG1 PPP3CA PPP3CB PPP3CC PRKCA PRKCB MAPK3 MAPK8 MAP2K1 PTPN7 RAC1 RAF1 RASA1 RELA MAP2K4 SHC1 SOS1 TRA@ TRB@ VAV1 ZAP70 CALM1 CALM2 CALM3 CD3D CD3E CD3G CD247
tcytotoxicPathway T Cytotoxic Cell Surface Molecules ICAM1 ITGAL ITGB2 PTPRC TRA@ TRB@ THY1 CD2 CD3D CD3E CD3G CD247 CD8A CD28
thelperPathway T Helper Cell Surface Molecules ICAM1 ITGAL ITGB2 PTPRC TRA@ TRB@ THY1 CD2 CD3D CD3E CD3G CD247 CD4 CD28
tall1Pathway TACI and BCMA stimulation of B cell immune responses. TNFSF13B CHUK TNFRSF13C MAPK14 TNFRSF13B NFKB1 MAPK8 RELA TNFRSF17 TRAF2 TRAF3 TRAF5 TRAF6 TNFSF13 MAP3K14
telPathway Telomeres, Telomerase, Cellular Aging, and Immortality EGFR AKT1 XRCC6 HSP90AA1 IGF1R KRAS MYC POLR2A PPP2CA PRKCA RB1 BCL2 TEP1 TERF1 TERT TP53 XRCC5 TNKS
tgfbPathway TGF beta signaling pathway MAP3K7IP1 CREBBP EP300 APC SMAD2 SMAD3 SMAD4 SMAD7 MAPK3 MAP2K1 SKIL MAP3K7 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 ZFYVE9 CDH1
th1th2Pathway Th1/Th2 Differentiation HLA-DRA HLA-DRB1 IFNG IFNGR1 IFNGR2 IL2 IL2RA IL4 IL4R IL12A IL12B IL12RB1 IL12RB2 IL18 IL18R1 CD28 CD86 CD40 CD40LG
41bbPathway The 4-1BB-dependent immune response MAP4K5 CHUK ATF2 MAPK14 IFNG IKBKB IL2 IL4 TNFRSF9 JUN MAP3K1 MAP3K5 NFKB1 NFKBIA MAPK8 RELA TRAF2
ctla4Pathway The Co-Stimulatory Signal During T-cell Activation CTLA4 ICOSLG GRB2 ICOS HLA-DRA HLA-DRB1 IL2 ITK LCK PIK3CA PIK3R1 PTPN11 TRA@ TRB@ CD3D CD3E CD3G CD247 CD28 CD80 CD86
longevityPathway The IGF-1 Receptor and Longevity AKT1 FOXO3 GH1 GHR HRAS IGF1 IGF1R PIK3CA PIK3CG PIK3R1 SHC1 SOD1 SOD2 SOD3 CAT
pcafpathway The information-processing pathway at the IFN-beta enhancer ATF2 CREBBP HMGB1 JUN NFKB1 POLR2A RELA KAT2B
prc2Pathway The PRC2 Complex Sets Long term Gene Silencing Through Modification of Histone Tails HDAC1 HDAC2
eosinophilsPathway The Role of Eosinophils in the Chemokine Network of Allergy CCR3 CSF2 HLA-DRA HLA-DRB1 IL3 IL5 CCL5 CCL11
eea1Pathway The role of FYVE-finger proteins in vesicle transport EGF EGFR RAB5A TF TFRC EEA1 HGS
SARSpathway The SARS-coronavirus Life Cycle CKM MAPK14 EIF4E FBL GPT ANPEP LDHA LDHB LDHC NCL
Par1Pathway Thrombin signaling and protease-activated receptors GNA13 ADCY1 ARHGEF19 F2 F2R PTK2B ARHGEF15 ARHGEF9 PLCB1 ARHGEF12 ARHGEF18 ARHGEF16 GNA12 GNAI1 GNAQ GNB1 GNGT1 RHOA PPP1R12B ARHGEF4 ARHGEF3 PIK3CA PIK3CG PIK3R1 PRKCA PRKCB ROCK1 MAP3K7 ARHGEF5 ARHGEF7 F2RL3 ARHGEF1 ARHGEF2 ARHGEF6 ARHGEF10 ARHGEF11 ARHGEF17
stressPathway TNF/Stress Related Signaling TANK CHUK MAPK14 IKBKB JUN LTA MAP3K1 ATF1 NFKB1 NFKBIA MAPK8 MAP2K3 MAP2K6 MAP4K2 RELA MAP2K4 TNF TNFRSF1A TRAF2 CASP2 IKBKG TRADD RIPK1 CRADD MAP3K14
tnfr1Pathway TNFR1 Signaling Pathway PARP1 DFFA DFFB JUN ARHGDIB LMNA LMNB1 MAP3K1 PAK1 PAK2 PRKDC MAPK8 RB1 MAP2K4 SPTAN1 MAP3K7 TNF TNFRSF1A TRAF2 CASP2 CASP3 CASP8 LMNB2 MADD TRADD RIPK1 CRADD FADD BAG4
tnfr2Pathway TNFR2 Signaling Pathway TANK CHUK DUSP1 IKBKB LTA MAP3K1 NFKB1 NFKBIA RELA TNFAIP3 TNFRSF1B TRAF1 TRAF2 TRAF3 IKBKG IKBKAP RIPK1 MAP3K14
tollPathway Toll-Like Receptor Pathway TLR6 MAP3K7IP1 TIRAP CHUK MAPK14 ELK1 MAP3K7IP2 FOS LY96 IKBKB IRAK1 JUN MAP3K1 MYD88 NFKB1 NFKBIA TLR7 ECSIT TLR9 TOLLIP PPARA MAPK8 MAP2K3 MAP2K6 EIF2AK2 RELA MAP2K4 MAP3K7 TLR2 TLR3 TLR4 TRAF6 TLR10 IKBKG PGLYRP1 MAP3K14 CD14
TPOPathway TPO Signaling Pathway CSNK2A1 FOS GRB2 HRAS JAK2 JUN MPL PIK3CA PIK3CG PIK3R1 PLCG1 PRKCA PRKCB MAPK3 MAP2K1 RAF1 RASA1 SHC1 SOS1 STAT1 STAT3 STAT5A STAT5B THPO
crebPathway Transcription factor CREB and its extracellular signals ADCY1 CREB1 MAPK14 AKT1 GNAS GRB2 HRAS PIK3CA PIK3R1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB MAPK1 MAPK3 RAC1 RPS6KA1 SOS1 CAMK2A CAMK2B CAMK2D CAMK2G RPS6KA5
carm1Pathway Transcription Regulation by Methyltransferase of CARM1 CARM1 CREB1 CREBBP EP300 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RARA RXRA NCOA3
tffPathway Trefoil Factors Initiate Mucosal Healing CTNNB1 EGFR AKT1 GH1 GHR GRB2 APAF1 HRAS ITGB1 RHOA PIK3CA PIK3CG PIK3R1 CYCS MAPK1 MAPK3 BAD PTK2 SHC1 SOS1 CASP9
trkaPathway Trka Receptor Signaling Pathway AKT1 GRB2 HRAS NGF NTRK1 PIK3CA PIK3R1 PLCG1 PRKCA PRKCB SHC1 SOS1
tsp1Pathway TSP-1 Induced Apoptosis in Microvascular Endothelial Cell MAPK14 FOS FYN JUN THBS1 CASP3 CD36
arfPathway Tumor Suppressor Arf Inhibits Ribosomal Biogenesis CDKN2A E2F1 ABL1 POLR1A MDM2 MYC POLR1D PIK3CA PIK3CG PIK3R1 RAC1 RB1 TBX2 TP53 TWIST1 POLR1B POLR1C
ucalpainPathway uCalpain and friends in Cell spread ITGA1 ITGB1 ITGB3 RHOA PTK2 ACTA1 PXN RAC1 SPTAN1 SRC TLN1 EZR CAPN1 CAPNS1 CAPNS2 ACTN1 ACTN2 ACTN3
vegfPathway VEGF, Hypoxia, and Angiogenesis EIF1 EIF1AX EIF2S1 EIF2B1 EIF2S3 ELAVL1 FLT1 FLT4 HIF1A HRAS KDR ARNT NOS3 PIK3CA PIK3CG PIK3R1 PLCG1 PRKCA PRKCB PTK2 PXN SHC1 VEGFA VHL EIF2B4 EIF2B3 EIF2B2 EIF2B5 EIF2S2
vobesityPathway Visceral Fat Deposits and the Metabolic Syndrome NR3C1 HSD11B1 LPL PPARG RETN RXRA TNF ADIPOQ
vitCBPathway Vitamin C in the Brain COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 P4HB SLC2A1 SLC2A3 SLC23A2 SLC23A1
wntPathway WNT Signaling Pathway FRAT1 MAP3K7IP1 WIF1 CREBBP CSNK1A1 CSNK1D CSNK2A1 CTBP1 CTNNB1 DVL1 GSK3B HDAC1 APC SMAD4 MYC LEF1 NLK PPARD PPP2CA CCND1 MAP3K7 TLE1 WNT1 AXIN1 FZD1 BTRC
actinYPathway Y branching of actin filaments ARPC5 ARPC4 ARPC3 ARPC1B ACTR3 ACTR2 ARPC2 ABI2 WASF2 ARPC1A NCKAP1 WASF3 NCK1 NTRK1 PSMA7 ACTA1 RAC1 PIR WASF1 WASL
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