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| ProductDetails | |
|---|---|
| Synonyms | Q-Val-Asp-OPh;pan-CaspaseInhibitor;N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy)methylketone |
| ProductType | Chemical |
| Properties | |
| Formula | C26H25F2N3O6 |
| MW | 513.5 |
| CAS | 1135695-98-5(anhydrous) |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥95%(TLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO. |
| BiologicalActivity | TheIC50rangeforcaspases-1,-3,-8,-9,-10,and-12is25-400nM. |
| OtherProductData | Q-VD-OPhdoesnotexhibittoxiceffectsattypicalworkingconcentrations:10-20μMforinvitrocellcultureapplications,10-120(upto1000)mg/kgforinvivoanimalstudies.Q-VD-OPhisasmallhydrophobiccompoundandrequiresDMSOforsolubilization.Stocksolutionsashighas200mg/mlhavebeenpreparedinDMSO.Toretainsolubilityinwateratconcentrationsabove1mg/ml,80%DMSOissuggested.Fortissueculturestudies10mMor20mMstocksolutionsarepreparedinDMSOanddiluted1:1000directlyintothetissueculturemedium.ForinvivostudiesQ-VD-OPhhasbeenadministeredin80%to100%DMSOtoassuresolubilityatthedosesgiven. ForNegativeControlseeProd.No.AG-CP3-0007. |
| InChiKey | OOBJCYKITXPCNS-AKRCKQFNSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/Stability | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |