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Adipogen/BEZ235/SYN1018M001/1 mg
MoreInformation
ProductDetails
SynonymsNVP-BEZ235;BEZ-235
ProductTypeChemical
Properties
FormulaC30H23N5O
MW469.6
CAS915019-65-7
PurityChemicals≥95%
AppearanceSolid.
SolubilitySolubleinDMSOorethanol.
DeclarationManufacturedbySynKinase.
OtherProductDataTarget:mTOR-PI3K|KinaseGroup:Atypical(PIKK)|Substrate:Serine-Threonine

ClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKeyJOGKUKXHTYWRGZ-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
NVP-BEZ235isanimidazo[4,5-c]quinolinederivativethatinhibitsPI3KandmTORkinaseactivitybybindingtotheATP-bindingcleftoftheseenzymes.Incellularsettingsusinghumantumorcelllines,thismoleculeisabletoeffectivelyandspecificallyblockthedysfunctionalactivationofthePI3Kpathway,inducingG1arrestatIC(50)values3-10nMinbiologicalcellgrowthandviabilityassays.InadditionNVP-BEZ235showseffectiveIC(50)valuesininvitrotestsagainstmTorandPI3Kfamilymembersof10nM.
ProductReferences
  1. IdentificationandcharacterizationofNVP-BEZ235,aneworallyavailabledualphosphatidylinositol3-kinase/mammaliantargetofrapamycininhibitorwithpotentinvivoantitumoractivity.S.M.Maira,etal.;Mol.CancerTher.7,1851(2008)
  2. Recentresultsinproteinkinaseinhibitionfortropicaldiseases.D.P.Rotella,etal.;Bioorg.Med.Chem.Lett.22,6788(2012)

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