Adipogen/Cyclopamine/AGCN20028M005/5 mg

MoreInformation
ProductDetails
Synonyms	11-Deoxyjervine;11-Deoxojervine;HSDB3505
ProductType	Chemical
Properties
Formula	C₂₇H₄₁NO₂
MW	411.6
CAS	4449-51-8
Source/HostChemicals	IsolatedfromVeratrumcalifornicum.
PurityChemicals	≥98%
Appearance	Whitetooff-whitesolid.
Solubility	Solubleinethanol,methanol,DMForDMSO.Insolubleinwater.
InChiKey	QASFUMOKHFSJGL-LAFRSMQTSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
HandlingAdvice	Protectfromlight.
Use/Stability	Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Cellpermeablesteroidalalkaloid.
Specificsonichedgehog(Shh)signalingpathwayinhibitor.Directlyinteracts/inhibitsSmo(smoothened)[1-4].
Teratogenic[1]andantitumorcompound.Inhibitstumorcellgrowthandprogression.ShowsselectiveactivityagainstShh-dependenttumors[5-11].
BlocksabnormalcellgrowthassociatedwithoncogenicmutationsofPtchandSmoinfibroblasts[2].
ArrestscellcycleatG0/G1[6].
Apoptosisinducer[8].

ProductReferences

TheteratogenicVeratrumalkaloidcyclopamineinhibitssonichedgehogsignaltransduction:J.P.Incardona,etal.;Development125,3553(1998)
Pancreasdevelopmentispromotedbycyclopamine,ahedgehogsignalinginhibitor:S.K.Kim&D.A.Melton;PNAS95,13036(1998)
EffectsofoncogenicmutationsinSmoothenedandPatchedcanbereversedbycyclopamine:J.Taipale,etal;Nature406,1005(2000)
InhibitionofHedgehogsignalingbydirectbindingofcyclopaminetoSmoothened:J.K.Chen,etal.;GenesDev.16,2743(2002)
Hedgehogsignallingincolorectaltumourcells:inductionofapoptosiswithcyclopaminetreatment:D.Qualtrough,etal.;Int.J.Cancer110,831(2004)
Thehedgehogpathwayinhibitorcyclopamineincreaseslevelsofp27,anddecreasesbothexpressionofIGF-IIandactivationofAktinPC-3prostatecancercells:R.J.Levitt,etal.;CancerLett.255,300(2007)
Cyclopamine-mediatedhedgehogpathwayinhibitiondepletesstem-likecancercellsinglioblastoma:E.E.Bar,etal.;StemCells25,2524(2007)
Thehedgehoginhibitorcyclopamineinducesapoptosisinleukemiccellsinvitro:J.Warzecha,etal.;Leuk.Lymph.49,2383(2008)
CyclopamineinhibitionofhumanbreastcancercellgrowthindependentofSmoothened(Smo):X.Zhang,etal.;BreastCancerRes.Treat.115,505(2009)
Cyclopamineandhedgehogsignaling:chemistry,biology,medicalperspectives:P.Heretsch,etal.;Chem.Int.Ed.Engl.49,3418(2010) (Review)
Targetingthehedgehogpathway:thedevelopmentofcyclopamineandthedevelopmentofanti-cancerdrugstargetingthehedgehogpathway:A.Gould&S.Missailidis;MiniRev.Med.Chem.11,200(2011)(Review)