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Adipogen/AcTrpLeuAlaAMC [AcWLAAMC]/SBBPS0008M002/2 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/AcTrpLeuAlaAMC [AcWLAAMC]/SBBPS0008M002/2 mg

MoreInformation
ProductDetails
SynonymsProteasomeSubstrate
ProductTypeChemical
Properties
FormulaC32H37N5O6
MW587.7
SequenceAcetyl-Trp-Leu-Ala-7-amido-4-methylcoumarin
CAS1104011-59-7
PurityChemicals≥99%(HPLC)
AppearanceLyophilizedpowder.
SolubilitySolubleinDMSO.
DeclarationManufacturedbySouthBayBio.
OtherProductDataUse:AfterpreparingastocksolutioninDMSO(≥10mM)storeproductat-20°Cto-80°C.Itisrecommendedtomakemultiplealiquotsafterthefirstthawtoensurebestperformance.Chymotrypsin-likeactivitycanbemeasuredusingatypicalworkingconcentrationrangefrom10-50µM.ClickhereforaTypicalLot-specificProductDatasheetfromtheOriginalManufacturer
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKeyPIJMRHCPKXLMIS-DOYMOWJKSA-N
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceAvoidfreeze/thawcycles.
Protectfromlight.
Use/StabilityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
Ac-WLA-AMCisafluorogenicpeptidsubstrateformeasuringchymotrypsin-likeactivityoftheproteasome.Hydrolysisofthissubstratebytheβ5-subunitofthe20SproteasomeismonitoredbyobservingfluorescenceatanExcitationwavelengthof345nmandEmissionat445nm.Thissubstrateisspecifictotheconstitutiveproteasomeandisnothydrolyzedefficientlybytheimmunoproteasome.20SProteasomeenzymerequiresactivationwith0.035%SDSintheassaybuffer.
ProductReferences
  1. Characterizationofanewseriesofnon-covalentproteasomeinhibitorswithexquisitepotencyandselectivityforthe20Sβ5-subunit:C.Blackburn,etal.;Biochem.J.430,461(2010)
  2. Theimmunoproteasomeasatherapeutictargetforhematologicalmalignancies:Z.Miller,etal.;Curr.Can.DrugTargets14,537(2014)
  3. Immunoproteasome-selectiveinhibitors:apromisingstrategytotreathematologicmalignancies,autoimmuneandinflammatorydiseases:R.Ettari,etal.;Curr.Med.Chem.23,1217(2016)

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