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Adipogen/KN93 (water soluble)/AGCR10065M005/5 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/KN93 (water soluble)/AGCR10065M005/5 mg
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ProductDetails
Synonyms2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
ProductTypeChemical
Properties
FormulaC26H29ClN2O4S.H3PO4
MW501.0.98.0
CAS1188890-41-6|139298-40-1(freebase)
PurityChemicals≥98%(HPLC)
AppearanceWhitetooff-whitesolid.
SolubilitySolubleinwater.
OtherProductDataStocksolutionsarestableforupto3monthswhenstoredat-20°C.
InChiKeyLHFKHAVGGJJQFF-UEOYEZOQSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceHygroscopic.
Protectfromlight.
Use/StabilityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
  • SelectiveCa2+/calmodulin-dependentproteinkinaseIIinhibitor[1].
  • Insulinreleaseinhibitor[2].
  • Acidsecretioninhibitor[3].
  • G1cellcyclearrestinducer[4].
  • Apoptosisinducer[4,7].
  • Ionchannelinhibitor[5,6].
  • ROSinducer[7].
  • Androgenreceptorinhibitor[7].
ProductReferences
  1. ThenewlysynthesizedselectiveCa2+/calmodulindependentproteinkinaseIIinhibitorKN-93reducesdopaminecontentsinPC12hcells:M.Sumi,etal.;BBRC181,968(1991)
  2. PresenceandpossibleinvolvementofCa/calmodulin-dependentproteinkinasesininsulinreleasefromtheratpancreaticbetacell:I.Niki,etal.;BBRC&191,255(1993)
  3. InhibitionofacidsecretioningastricparietalcellsbytheCa2+/calmodulin-dependentproteinkinaseIIinhibitorKN-93:N.Mamiya,etal.;BBRC195,608(1993)
  4. G1cellcyclearrestandapoptosisareinducedinNIH3T3cellsbyKN-93,aninhibitorofCaMK-II(themultifunctionalCa2+/CaMkinase):R.M.Tombes,etal.;CellGrowthDiffer.6,1063(1995)
  5. CaMKII-independenteffectsofKN93anditsinactiveanalogKN92:reversibleinhibitionofL-typecalciumchannels:L.Gao,etal.;BBRC345,1606(2006)
  6. KN-93(2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine),acalcium/calmodulin-dependentproteinkinaseIIinhibitor,isadirectextracellularblockerofvoltage-gatedpotassiumchannels:S.Reazadeh,etal.;J.Pharmacol.Exp.Ther.317,292(2006)
  7. KN-93inhibitsandrogenreceptoractivityandinducescelldeathirrespectiveofp53andAktstatusinprostatecancer:O.W.Rokhlin,etal.;CancerBiol.Ther.9,224(2010)

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