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Adipogen/PD 150,606/AGCR10066M005/5 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/PD 150,606/AGCR10066M005/5 mg
MoreInformation
ProductDetails
Synonyms3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoicacid
ProductTypeChemical
Properties
FormulaC9H7IO2S
MW306.1
CAS426821-41-2
PurityChemicals≥98%(NMR)
AppearanceOff-whitesolid.
SolubilitySolubleinDMSOormethanol.
IdentityDeterminedby1H-NMR.
InChiKeyDJCVSFWGKYHMKH-YVMONPNESA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceKeepunderinertgas.
Protectfromlight.
Use/StabilityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
  • Cellpermeableandselectivecalpain-1and-2inhibitor[1,3].
  • Interactswithcalcium-bindingdomainofcalpain[2,4].
  • Neuroprotective[2].
  • Ca2+-permeableAMPAreceptorinhibitor[5].
  • Apoptosisinhibitor[6]
  • AutophagyactivatorbypreventingcleavageofATG5[7.]
ProductReferences
  1. Modulationofhypoxia-inducedcalpainactivityinratrenalproximaltubules:C.L.Edelstein,etal.;KidneyInt.50,1150(1996)
  2. Analpha-mercaptoacrylicacidderivativeisaselectivenonpeptidecell-permeablecalpaininhibitorandisneuroprotective:K.K.Wang,etal.;PNAS93,6687(1996)
  3. Alpha-mercaptoacrylicacidderivativesasnovelselectivecalpaininhibitors:K.K.Wang,etal.;Adv.Exp.Med.Biol.389,95(1996)
  4. CrystalstructureofcalciumbounddomainVIofcalpainat1.9Aresolutionanditsroleinenzymeassembly,regulation,andinhibitorbinding:G.D.Lin,etal.;Nat.Struct.Biol.4,539(1997)
  5. Analpha-mercaptoacrylicacidderivative(PD150606)inhibitsselectivemotorneurondeathviainhibitionofkainate-inducedCa2+influxandnotviacalpaininhibition:L.VandenBosch,etal.;Neuropharmacology42,706(2002)
  6. Calpain,anupstreamregulatorofthymocyteapoptosis:M.K.Squier&J.J.Cohen;J.Immunol.158,3690(1997)
  7. Post-translationalcontrolofIL-1βviathehumanpapillomavirustype16E6oncoprotein:anovelmechanismofinnateimmuneescapemediatedbytheE3-ubiquitinligaseE6-APandp53:M.Niebler,etal.;PLoSPathog.9,e1003536(2013)

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