Chlormadinoneisasyntheticsteroidalprogesteronethatexhibitsanti-androgenicandanti-osteoporoticactivities.Chlormadinoneisoccasionallyusedasacontraceptivebutalsotreatsbenignprostatichyperplasia(BPH)andpolycysticovarysyndrome(PCOS).Inbonemarrowstemcells,chlormadinonepromotesosteoblastdifferentiationandCa2+deposition.
| CasNo. | 302-22-7 |
|---|---|
| Purity | ≥96% |
| Formula | C23H29ClO4 |
| FormulaWt. | 404.93 |
| ChemicalName | 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione |
| IUPACName | [(8R,9S,10R,13S,14S,17R)-17-acetyl-6-chloro-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]acetate |
| Synonym | ChronosynlCyclonorm;Fertiletten;Lormin;Luteran;Matrol;Normenon;Prostal;Traslan |
| MeltingPoint | 212-214°C |
| Solubility | Solubleinmethanolorether. |
| Appearance | WhiteorOff-whiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | C2847MSDSPDF |
|---|---|
| InfoSheet | C2847InfoSheetPDF |
KimJM,LeeJE,RyuSH,etal.ChlormadinoneacetatepromotesosteoblastdifferentiationofhumanmesenchymalstemcellsthroughtheERKsignalingpathway.EurJPharmacol.2014Mar5;726:1-8.PMID:24440171.
FujimotoK,HiraoY,OhashiY,etal.Theeffectsofchlormadinoneacetateonlowerurinarytractsymptomsanderectilefunctionsofpatientswithbenignprostatichyperplasia:aprospectivemulticenterclinicalstudy.AdvUrol.2013;2013:584678.PMID:23762042.
GomesVA,VieiraCS,Jacob-FerreiraAL,etal.Oralcontraceptivecontainingchlormadinoneacetateandethinylestradiolreducesplasmaconcentrationsofmatrixmetalloproteinase-2inwomenwithpolycysticovarysyndrome.BasicClinPharmacolToxicol.2012Sep;111(3):211-6.PMID:22510229.