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| ProductDetails | |
|---|---|
| Synonyms | V-typeImmunoglobulinDomain-containingSuppressorofTCellActivation;PlateletReceptorGi24;Stress-inducedSecretedProtein-1;Sisp-1;V-setDomain-containingImmunoregulatoryReceptor |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | TheextracellulardomainofhumanVISTA(B7-H5)(aa33-194)isfusedattheC-terminustoaHis-tag. |
| Crossreactivity | Human |
| MW | ~30-40kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 0.1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith100μlsterilewater. |
| AccessionNumber | Q9H7M9 |
| Formulation | Lyophilized.ContainsPBS. |
| OtherProductData | UniProtlinkQ9H7M9:VISTA(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/Stability | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
HumanVISTAisa55to65kDatypeIIgmembraneproteinwiththeextracellulardomainhomologoustoPD-L1.VISTAismainlyexpressedonhematopoietictissues(spleen,thymusandbonemarrow)andonmyeloidcellswithlowerexpressiononCD4+andCD8+Tcells.VISTAisanewnegativecheckpointregulatorthatpotentlysuppressesTcellactivation.OverexpressionofVISTAontumorsinhibitstheprotectiveanti-tumorimmunityandblockadeofVISTAenhancesantitumorimmunityinmultipletumormodels.VISTAonantigenpresentingcells(APC)deliversnegativesignalingtoTcellsviaayet-to-identifybindingpartneronTcells.