提供全套的蛋白、肽生物素化的产品，其主要产品包括：生物素蛋白连接酶（BirA）；生物素化菌株；AviTag载体；生物素化重组蛋白.

Avidity,LLCwasfoundedin1996byMillardCull,LarryLansing,Dr.RonGill,andDr.MarkSevilletodeveloppeptidetagsandmolecularbiologyproductsbasedupontheextraordinaryaffinityofbiotinforavidinorstreptavidin.WhileworkingatAffymaxasaresearcher,MillardwasinvolvedinthediscoveryoftheAviTagtechnology,sawitscommercialpotential,andobtainedtheexclusiverightsfromAffymax.HestartedAvidityasareagentcompanythatsublicensestherighttousetheAviTagtechnologytoothercompaniesandsellsproductsforusewiththetechnology.

Avidity带有AviTag标签的人类全长ORF克隆已经被构建在多种T7和CMV启动子表达系统,可以立即购买使用。AviTag标签蛋白可以被体内或体外的生物素连接酶生物素化，而且抗生物素蛋白或链霉亲和素可以专一地与生物素结合，正基于这两个反应，AviTag?技术可以应用于蛋白的固定，纯化和显影。虽然Avidity是一个小公司，科学带来的好处及其AviTag已得到认可。目前，AviTag技术已经在22个国家的世界十大制药公司和研究人员中得到认可。 

AvidityAvitag™Technology

Avidity developsandsellsmolecularaffinitytoolsforconnectingmolecules.OurpatentedAviTag™technologyemploysahighlytargetedenzymaticconjugationofasinglebiotinonaunique15aminoacidpeptidetagusingthebiotinligase(BirA)fromE.coli.AviTag™sequenceisGLNDIFEAQKIEWHE.Orientedonstreptavidin-coatedsurfaces,thiscreatesanidealpresentationformolecularbindinginteractions.

ThescientificbenefitsofAvidity"sAviTagTechnologyhavegarnerednotice.Currently,AviTagtechnologyislicensedbysevenoftheworld"stoptenpharmaceuticalcompaniesandisusedbyresearchersin22countries.

CompanyHistory

Avidity,LLCwasfoundedin1996byMillardCull,LarryLansing,Dr.RonGill,andDr.MarkSevilletodeveloppeptidetagsandmolecularbiologyproductsbasedupontheextraordinaryaffinityofbiotinforavidinorstreptavidin.WhileworkingatAffymaxasaresearcher,MillardwasinvolvedinthediscoveryoftheAviTagtechnology,sawitscommercialpotential,andobtainedtheexclusiverightsfromAffymax.HestartedAvidityasareagentcompanythatsublicensestherighttousetheAviTagtechnologytoothercompaniesandsellsproductsforusewiththetechnology.

AviTagHistory

AviTagisapatentedbiotin-taggingtechnologydiscoveredatAffymaxbyDr.PeterSchatzfromaDirectedEvolutionapproachcalled"Peptides-on-Plasmids."TheDirectedEvolutionapproachidentifiedanumberofpeptidesequencesthatcanbebiotinylatedbytheBirAenzymeofE.coli,andthebestofthesesequenceswascalledtheAviTag.E.colienzymeBirAbiotinylatesthe15aminoacidAviTagtwiceasfastasitsnaturalsubstrate,theBiotinCarboxylCarrierProtein(BCCP).

TheenzymaticbiotinylationofproteinsusingAviTagtechnologyispreferredoverchemicalbiotinylationofproteinsbecauseBirAenzymegently,andhighlyspecifically,labelsthelysineresidueoftheAviTag.PriortotheAviTag,thesmallestbiotin-acceptingdomainwascomprisedof75aminoacids.

Avidity研发和销售用于分子连接的分子亲和工具，其的AviTag™技术采用针对性很强的一个独特的15氨基酸肽，用来自大肠杆菌的生物素连接酶（BirA）标签上的单一的生物素酶的共轭。

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