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FabGennix/MAPK11 Antibody/MAPK11-101Y

  • Description

General Information

Product

MAPK11 Antibody

Description

Affinity Purified Mitogen-activated protein kinase 11 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse,Rat

Immunogen

Synthetic peptide taken within amino acid region 300-350 on human Mitogen-activated protein kinase 11.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage

Application Protocol

ELISA

1:10,000

Immunohistochemistry1:50-1:100

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q15759

Overview

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm, Nucleus

Expression

Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.

Structure

Interacts with HDAC3 and DUSP16.

Alternative Nomenclature

Human p38Beta MAP kinase mRNA complete cds antibodyMAP kinase 11 antibodyMAP kinase p38 beta antibodyMitogen activated protein kinase 11 antibodyMitogen activated protein kinase p38 2 antibodyMitogen-activated protein kinase p38 beta antibodyMK11_HUMAN antibody p38Beta antibody PRKM11 antibodyProtein kinase mitogen activated 11 antibodySAPK2B antibody Stress activated protein kinase 2b antibody

Protein information supplied by UniProt

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