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Cellagentech/LDN193189 | BMP type I receptors ALK2/3 inhibitor/C53612s/2 mg (10 mM solution in DMS188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/LDN193189 | BMP type I receptors ALK2/3 inhibitor/C53612s/2 mg (10 mM solution in DMS
ProductDescription

LDN193189isahighlypotentBMPinhibitor,preventsSmad1,Smad5,andSmad8phosphorylationthroughinhibitionofBMPtypeIreceptorsALK2(IC50=5nM)andALK3(IC50=30nM).ItsinhibitionsagainstALK4,ALK5,andALK7areweak(IC50>500nM).AsBMPsignalingcoordinatesdevelopmentalpatterningandhasessentialphysiologicalrolesinmatureorganisms,LDN-193189isusedtoreduceectopicossificationinamousemodel.

ProductCitation

Technicalinformation:

ChemicalFormula: C25H22N6C25H22N6
CAS#: 1062368-24-4
MolecularWeight: 406.48
Purity: >98%
Appearance: Yellowsolid
ChemicalName: 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Solubility: Upto100mMinDMSO

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storage:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.PaulBYu,etal.BMPtypeIreceptorinhibitionreducesheterotopicossification.NatureMed.(2008)14:1363-1369.
2.CunyGD,etal.Structure-activityrelationshipstudyofbonemorphogeneticprotein(BMP)signalinginhibitors.BioorgMedChemLett.(2008)18(15):4388-92.
3.PaulBYu,etal.DorsomorphininhibitsBMPsignalsrequiredforembryogenesisandironmetabolism.NatureChemBiol.(2008)4:33-41.


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