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| AlternativeName: | CB1,CNR1,CBR |
| Host: | Rabbit |
| Immunogen: | SyntheticpeptidecorrespondingtothesequenceneartheN-terminusofmousecannABInoidreceptorCB1. |
| UniProtID: | P47746 |
| Speciesreactivity: | Human,Mouse,Rat Chicken |
| Crossreactivity: | Predictedspeciesreactivitybasedonepitopesequencehomology:gorilla,guineapig,horse,dog,cat,platypus,ZebraFinch(bird). |
| Applications: | WB |
| ApplicationNotes: | PredictedMWof~53kDa.HigherMWspeciesmayalsobeobservedbyWesternblotwhichreflectpost-translationalmodificationofthereceptor. |
| PurityDetail: | Peptideaffinitypurified. |
| Formulation: | Liquid.InPBScontaining50%glyceroland0.01%sodiumazide. |
| Handling: | Keeponiceatalltimes. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | -20°C |
| ScientificBackground: | ThecannabinoidreceptorsCB1andCB2aremembersoftheseven-transmembranefamilyofG-proteincoupledreceptors(GPCRs),andarenamedfortheirsignalingfunctioninresponsetocannabinoiddrugssuchasdelta9-tetrahydrocannabinol(delta9-THC).CB1andCB2differsignificantlyinthelengthoftheirextracellularaminoterminaldomain,whichislongerinCB1(116residues)thaninCB2(33residues).TheCB1receptorisexpressedprimarilyinthebrainandneuronaltissue,andishighlyconserved,exhibiting97-98%aminoacidsequenceidentityacrosshuman,mouse,andratspecies.Incontrast,expressionoftheCB2receptorisabsentinnormalnervoustissue,withexpressionmostprominentinimmunetissuesuchasthespleen.Inadditiontodelta9-THCanditssyntheticanalogs,CB1andCB2receptorsareboundbyendogenouseicosanoidligands,andsignalviaGi/oproteinstoregulateadenylylcyclaseactivity(generallyinhibitory),ionchannelactivation,intracellularCa2+levels,nitricoxidesynthaseactivation,andimmediateearlygeneexpression.CB1andCB2signalsinturnregulateneurologicalandimmunologicalfunctionssuchasinhibitionofneurotransmitterreleaseandimmunecellmigration,antigenprocessing,andcytokineproduction. |
| Manufacturer: | ManufacturedbyProteimax. |