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Rockland/Anti-DDB1 Antibody/100-401-A09/100 µL

Anti-DDB1AntibodyProperties

Description
Anti-p127-DDB1(internal)(RABBIT)Antibody-100-401-A09
Host
Rabbit
TargetSpecies
Human
KnownCrossReactivity
human,mouse
Clonality
Polyclonal
Application
ELISA:1:2,000-1:10,000
WesternBlot:1:500-1:1,000
Immunohistochemistry:UserOptimized
ImmunoPrecipitation:1:500
OtherDilution:UserOptimized
PhysicalState
Liquid(sterilefiltered)
ShippingCondition
DryIce
Format
Antiserum
Label
Unconjugated
Concentration
85mg/mLbyRefractometry
Buffer
None
Preservative
0.01%(w/v)SodiumAzide
StABIlizer
None
GeneName
DDB1
RelevantLinks
UniProtKB-Q16531
NCBI-148529014
GeneID-1642

Anti-DDB1AntibodyDescription

Background
DDB1isalsoknownasdamage-specificDNAbindingprotein1,DDBp127subunit,DDBa,UV-damagedDNA-bindingprotein1,UV-DDB1,XerodermapigmentosumgroupEcomplementingprotein,XPCe,X-associatedprotein1andXAP-1. TheDDB1geneencodesthelargesubunit(p127)ofDNAdamage-bindingprotein,whichisaheterodimer,composedofalargeandasmallsubunit(p48DDB2).Thisnuclearproteinfunctionsinnucleotide-excisionrepairresultingfromUV-damagedDNAbybindingtopyrimidinedimers. ItsdefectiveactivitycausestherepairdefectinthepatientswithxerodermapigmentosumcomplementationgroupE(XPE).XP-Eisararehumanautosomalrecessivediseasecharacterizedbysolarsensitivity,highpredispositionfordevelopingcancersonareasexposedtosunlightand,insomecases,neurologicalabnormalities. DDB1antibodyisinvolvedinEpigeneticandCancer/DNADamageresearch.
Synonyms
rabbitanti-Anti-p127-DDB1antibody,DamagespecificDNAbindingprotein1antibody,DDB1antibody,DDBp127subunitantibody,DDBaantibody,DNAdamagebindingprotein1antibody,UVdamagedDNAbindingfactorantibody
Immunogen
DDB1antibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacids198-213ofHumanDDB1(internal)coupledtoKLH.
ImmunogenType
Peptide
StorageCondition
StoreAnti-DDB1at-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-DDB1antibodyreactswithhumanandmouse DDB1bywesternblotandimmunoprecipitation. Theantibodyimmunoprecipitatesinvitrotranslatedproteinandproteinfromcelllysates(usingHeLa,NIH-3T3,andothers). Coimmunoprecipitationofrelatedproteinshasnotbeentested. A127.0kDabandcorrespondingtohumanDDB1isdetected. MostcelllinesexpressingDDB1canbeusedasapositivecontrol. Researchersshoulddetermineoptimaltitersforotherapplications.
Purity/Specifity
Anti-DDB1ismonospecificantiserumprocessedbydelipidationanddefibrinationfollowedbysterilefiltration.ThisproductreactswithhumanandmouseDDB1. CrossreactivitywithDDB1fromothersourcesisnotknown.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
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