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Sciencell/Recombinant Human Angiostatin K1-3/103-09/1 Ea

Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
Angiostatinisaproteolyticfragmentofplasminogenandhasbeenshowntoactasapotentinhibitorofangiogenesis,particularlyendothelialcellproliferation,andtumorgrowth.AngiostatinK1-3isoformofangiostatinrobustlyinducestheexpressionofE-selectinmRNAviathebindingofAP1andEts-1transcriptionfactors.

Specifications:

CatalogNo.103-09
CountryofManufactureUnitedStates
ProductCoderhAngiostatinK1-3
Size/Quantity10μg
ProductUseThisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
StorageStoreat-20°Cafterreceiving.UponReconstitution,storeat2-8°Cforuptooneweek.FormaximalstABIlity,aliquotandstoreat-20°C.Avoidrepeatedfreeze/thawcycles.
ShippingInfoDryice
SynonymsAngiostatinKringles1-3,AngK1-3
AASequenceVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSP
SourceEscherichiacoli
MolecularWeightApproximately30.0kDa,asinglenon-glycosylatedpolypeptidechaincontaining259aminoacids.
Purity>95%bySDS-PAGEandHPLCanalyses.
BIOLOGicalActivityFullybiologicallyactive.Theactivityisassayedonanti-proliferationandanti-migrationofendothelialcellsinvitroandanti-angiogenesisinvivo.Thespecificactivityofanti-migrationofendo
PhysicalAppearanceWhitelyophilizedpowder.
FormulationLyophilizedfroma0.2μmfilteredconcentrated(1.0mg/ml)solutionin20mMNaAc,pH5.5,4%mannitol.
Endotoxin
ReconstitutionReconstituteinsteriledistilledwatercontaining0.1%BSAtoaconcentrationof0.1-1.0mg/mL.
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