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Sciencell/Recombinant Human IGF-BP3/105-01B3/1 Ea

Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
IGF-BP3isa30kDacysteine-richsecretedprotein.ItisthemajorIGFbindingproteinpresentintheplasmaofhumanandanimalsanditisalsofoundinα-granulesofplatelets.InadditiontoitsABIlitytomodulatetheactivityofIGF-IandIGF-II,IGF-BP3exertsinhibitoryeffectsonfolliclestimulatinghormone(FSH)activity.DecreasedplasmalevelsofIGF-BP3oftenresultsindwarfism,whereaselevatedlevelsofIGF-BP3mayleadtoacromegaly.TheexpressionofIGF-BP3infibroblastsisstimulatedbymitogenicgrowthfactorssuchasBombesin,Vasopressin,PDGF,andEGF.

Specifications:

CatalogNo.105-01B3
CountryofManufactureUnitedStates
ProductCoderhIGF-BP3
Size/Quantity5μg
ProductUseThisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
StorageStoreat-20°Cafterreceiving.UponReconstitution,storeat2-8°Cforuptooneweek.Formaximalstability,aliquotandstoreat-20°C.Avoidrepeatedfreeze/thawcycles.
ShippingInfoDryice
SynonymsGrowthhormonedependentbindingprotein,IBP3,BP-53
AASequenceGASSGGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGEVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
SourceEscherichiacoli
MolecularWeightApproximately28.8kDaproteinconsistingof264aminoacidresidues.
Purity>98%bySDS-PAGEandHPLCanalyses.
BIOLOGicalActivityFullybiologicallyactive.TheED50is≤0.2μg/mlinpresenceof15ng/mlofhumanIGF-II,asdeterminedbyitsabilitytoinhibitIGF-IIinducedMCF-7proliferation
PhysicalAppearanceWhitelyophilizedpowder.
FormulationLyophilizedfroma0.2μmfilteredconcentratedsolutioninPBS,pH7.4.
Endotoxin
ReconstitutionReconstituteinsteriledistilledwatercontaining0.1%BSAtoaconcentrationof0.1-1.0mg/mL.
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