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Sciencell/Recombinant Human Neurotrophin-4/107-04/1 Ea

Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
Neurotrophin-4(NT-4)isamemberoftheNGFfamilyofneuronalandepithelialgrowthfactors.Neurotrophinshavesixconservedcysteineresiduesthatareinvolvedintheformationofthreedisulfidebonds.HumanNT-4shares48-52%aminoacid(aa)sequenceidentitywithhumanbeta-NGF,BDNF,andNT-3.Itshares91%and95%identitywithmouseandratNT-4/5,respectively.ThematureproteinissecretedasahomodimerandcanalsoformheterodimerswithBDNForNT-3.NT-4bindsandinducesreceptordimerizationandactivationofTrkB.NT-4promotesthedevelopmentandsurvivalofselectedperipheralandCNSneurons.NT-4inducedTrkBsignalingaugmentsNMDAreceptoractivityandincreasesneuronalsensitivitytoexcitotoxiccelldeath.Italsopromotestheproliferationofkeratinocytesandaccelerateshairfollicleregressionduringthefollicularcycle.NT-4issecretedbyactivatedTcellsandgranulocytesatsitesofinflammationwhereitcontributestotissueregeneration.

Specifications:

CatalogNo.107-04
CountryofManufacture
ProductCoderhNT-4
Size/Quantity2μg
ProductUseThisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
StorageStoreat-20°Cafterreceiving.UponReconstitution,storeat2-8°Cforuptooneweek.FormaximalstABIlity,aliquotandstoreat-20°C.Avoidrepeatedfreeze/thawcycles.
ShippingInfoDryice
SynonymsNT-5,GLC10,GLC1O,NT-4/5
AASequenceGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA
SourceEscherichiacoli
MolecularWeightApproximately28kDa,anoncovalentlylinkedhomodimeroftwo14.0kDapolypeptidemonomers(260totalaminoacidresidues).
Purity>97%bySDS-PAGEandHPLCanalyses.
BIOLOGicalActivityFullybiologicallyactive.TheED50isis20-50ng/ml,asdeterminedbycholineacetyltransferaseactivityinratbasalforebrainprimaryseptalcellcultures
PhysicalAppearanceWhitelyophilizedpowder.
FormulationLyophilizedfroma0.2μmfilteredconcentrated(0.5mg/ml)solutionin20mMPB,pH7.4,150mMNaCl.
Endotoxin
ReconstitutionReconstituteinsteriledistilledwatercontaining0.1%BSAtoaconcentrationof0.1-1.0mg/mL.
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