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U-CyTech/F(ab')2 fragments of mAb anti-human IFN-γ (clone MD-1)/CT215-F/1 Ea188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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U-CyTech/F(ab')2 fragments of mAb anti-human IFN-γ (clone MD-1)/CT215-F/1 Ea

Description:


F(ab')2fragmentantibodiesaregeneratedbypepsindigestionofwholeIgGmonoclonalantibodiestohumanIFN-γ(cloneMD-1).F(ab')2fragmentshavetwoantigen-bindingF(ab)portionslinkedtogetherbydisulfidebonds,whiletheFcregionisremoved.F(ab')2fragmentseliminatenon-specificbindingbetweenFcportionsofantibodiesandFcreceptorsoncells(suchasmacrophages,dendriticcells,neutrophils,NKcellsandBcells). 

MD-1wasfirstdescribedin1985.IthasshowntoneutralizetheantiviralactivityofbothnaturalandrecombinanthumanIFN-γandinaWesternBlottheantibodyreactswiththe20kDaand25kDapolypeptidespresentinnaturalhumanIFN-γ(vanderMeideP.H.etal.1985).TheMD-1antibodyhasbeendescripedasusefulinasandwichELISAandinELISPOTassays(MeyaardL.etal.1996,ShenH.etal.2013,WassenaarA.etal.1995andWierengaE.A.etal.1990).Further,theantibodyhasproventocrossreactwithchimpanzeeandrhesusmacaqueIFN-γandcanbeusedforimmunohistochemicalstainingoffrozentissues(JonkerM.etal.2013andKapY.etal.2009).TheMD-1antibodyhasbeenreportedforuseinintracellularflowcytometricanalysis(HamannD.etal.1996)andinLuminexsystems(GiavedoniL.D.etal.2005).

Characteristics:

cloneMD-1[F(ab")2]
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