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Adipogen/antiTLR2, mAb (ABM3A87)/AG20T0300C100/100 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/antiTLR2, mAb (ABM3A87)/AG20T0300C100/100 µg

MoreInformation
ProductDetails
SynonymsToll-likeReceptor2;CD282;Toll/Interleukin-1Receptor-likeProtein4;TIL4
ProductTypeMonoclonalAntibody
Properties
CloneABM3A87
IsotypeMouseIgG1κ
Immunogen/AntigenRecombinanthumanTLR2protein(aa180-420).
ApplicationFlowCytometry:(0.5μg/106cells)
Immunohistochemistry:(5μg/ml;paraffinsections)
WesternBlot:(2-4μg/ml)
Optimalconditionsmustbedeterminedindividuallyforeachapplication.
CrossreactivityHuman
Mouse
SpecificityRecognizeshumanandmouseTLR2.
PurityProteinGpurified.
Concentration0.5mg/ml
FormulationLiquid.InPBScontaining0.05%BSAand0.05%sodiumazide.
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceAfteropening,preparealiquotsandstoreat-20°C.
Avoidfreeze/thawcycles.
Use/StABIlityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Stableforatleast6monthsafterreceiptwhenstoredat+4°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
TLR2(Toll-likeReceptor2)isamemberoftheTLR(Toll-likereceptor)familythatplaysafundamentalroleinpathogenrecognitionandactivationofinnateimmunity.TLR2actsviaMYD88andTRAF6,leADIngtoNF-κBactivation,cytokinesecretionandtheinflammatoryresponse.TLR2residesontheplasmamembranewhereitrespondstolipid-containingpathogen-associatedmolecularpatterns(PAMPs),suchaslipoteichoicacidanddi-andtri-acylatedcysteine-containinglipopeptides.ItdoesthisbyformingdimericcomplexeswitheitherTLR1orTLR6,whichconsequentlyistheinitialstepinacascadeofeventsleadingtosignificantinnateimmuneresponses,developmentofadaptiveimmunitytopathogensandprotectionfromimmunesequelaerelatedtoinfectionswiththesepathogens.TLR2alsointeractswithalargenumberofnon-TLRmoleculessuchasLY96(MD-2),allowingforrecognitionofagreatnumberandvarietyofPAMPs(pathogen-associatedmolecularpatterns).TLR2expressionhasbeendetectedinimmunecells,endothelialandepithelialcells.

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