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Adipogen/antiTLR3 (mouse), mAb (ABM24E5)/AG20T0302C100/100 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/antiTLR3 (mouse), mAb (ABM24E5)/AG20T0302C100/100 µg
MoreInformation
ProductDetails
SynonymsToll-likeReceptor3;CD283
ProductTypeMonoclonalAntibody
Properties
CloneABM24E5
IsotypeRatIgG2bκ
Immunogen/AntigenRecombinantmouseTLR3protein(aa180-385).
ApplicationFlowCytometry:(0.5mg/106cells)
WesternBlot:(2-4μg/ml)
Optimalconditionsmustbedeterminedindividuallyforeachapplication.
CrossreactivityMouse
SpecificityRecognizesmouseTLR3.
PurityProteinGpurified.
Concentration0.5mg/ml
FormulationLiquid.InPBScontaining0.05%BSAand0.05%sodiumazide.
AccessionNumberQ99MB1
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceAfteropening,preparealiquotsandstoreat-20°C.
Avoidfreeze/thawcycles.
Use/StABIlityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Stableforatleast6monthsafterreceiptwhenstoredat+4°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
TLR3(Toll-likeReceptor3)isamemberoftheTLR(Toll-likereceptor)familythatplaysafundamentalroleinpathogenrecognitionandactivationofinnateimmunity.mTLR3showshighhomologytohTLR3intheirpredictedCDNAandproteinsequences.TLR3isanucleotide-sensingTLR,activatedbydouble-strandedRNA(dsRNA)whichisassociatedwithviralinfection.AdditionaltodsRNAitbindsalsotosyntheticligandsmimickingdsRNA(suchasPolyI:C).ItactsviatheadapterTRIF/TICAM1andinducestheactivationofIRF3,ultimatelyinducingtheproductionoftypeIinterferons(IFNs).ThehighlevelsofmTLR3expressioninmarginalzoneBcellsperhapscontributetotheirabilitytoclearantigenfromtheblood.IthasbeendemonstratedextensivelythatTLR3activationleadstocross-primingofCD8+TcellsviamajorhistocompatibilitycomplexIforthegenerationofcytotoxicTcell(CTL)responses.TLR3displaysaprotectiveroleinmousemodelsofatherosclerosisandagainstbrainischemia.

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