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Cellagentech/SD169 | p38 MAPK inhibitor/C721610/10 mg (powder)

ProductDescription

SD169isanindole-5-carboxamide,orally-available,ATP-competitive,a-selectivep38MAPKinhibitorthattargetsawidevarietyofinflammatorycells,includingneutrophils,monocytes,macrophages,BandCD4+Tcells,andendothelialcells.[1]ThroughinteractionswithSchwanncellandTNFactivity,SD169promotesaxonalregenerationinperipheralnerves.[2]

SD169hasbeenshowntoreducemyeloma-inducedosteolyticbonelesionsandrestoredbonemassbydownregulatingosteoclastogenesisandosteoblastogenesisinxenograftedprimarymyeloma-SCID-huormyelomacellline-SCIDmousemodels.[3]SD169wasalsoshowndownregulatespp38inmyelomacellsinvitroandinvivo.

Inthediabetestherapeuticarea,SD169significantlyreducesp38andHSP60expressioninTcellsofthepancreaticbetaislets.InstudiesusinghyperglycemicNODmice,SD169treatmentloweredbloodglucoseandimprovedglucosehomeostasis.[4]


Technicalinformation:

ChemicalFormula: C9H8N2O
CAS#: 1670-87-7
MolecularWeight: 160.17
Purity: >98%
Appearance: White
ChemicalName: 1H-indole-5-carboxamide
Solubility: Upto22mMinDMSO
Synonyms: SD-169,SD169

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.


Reference:

1.Medicherlaetal.,p38MAPKinhibitionreducesdiabetes-inducedimpairmentofwoundhealing.Diabetes,Metab.Syndr.Obes.2009,2,91-100.PubmedID:21437122
2.Myersetal.,Inhibitionofp38MAPkinaseactivityenhancesaxonalregeneration.Exp.Neurol.2003,184,606-614.PubmedID:14769353
3.Yangetal.,Constitutiveactivationofp38MAPKintumorcellscontributestoosteolyticbonelesionsinmultiplemyeloma.Leukemia,2012,26,2114-2123.PubmedID:22425892
4.Medicherlaetal.,J.Pharmacol.Exp.Ther.2006,318(1),99-107.PubmedID:14769353


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