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Lee Biosolutions/Alpha-1 Antitrypsin (A1AT)/106-11-1/1 mg

Description
ProductNameAlpha-1-Antitrypsin
SourceHumanPlasma
CatalogueNumber106-11
Purity>95%(SDS-PAGE)
FormLyophilized
ProteinReportedinmg/vial(A280,E0.1%=0.433)
FormulationLyophilizedfromsodiumphosphatebuffer
ReconstitutionDe-ionizedH2O
Storage-20°C
Recertification3years
MolecularWeight~54,000
UNSPSCcode51131904
SynonymsA1AT,Alpha-1proteaseinhibitor,Alpha-1-antiproteinase
Applications
Controls/Calibrators/StandardsImmunoassaysClinicalChemistryAssayDevelopment/ValidationLifeScience
Overview

LeeBiosolutionsistheleADIngsupplierofhumanplasmaAlpha-1-Antitrypsin(A1AT)formedicalresearchanddiagnosticmanufacturing.

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Humanalpha1AntitrypsinorHumanA1-antitrypsin(A1AT),alsoknownasserumtrypsininhibitor,protectstissuefromenzymesfrominflammatorycells,especiallyelastaseandispresentinhumanblood.Disordersoftheenzymeincludehumanalpha-1antitrypsindeficiency,ahereditarydisorderinwhichlackofHumanalpha-1AntitrypsinAAT(A1AT)leadstouninhibitedtissuebreakdownduringinflammation.

Studiesindicatethatthiscausespulmonaryemphysemaandleadstolivercirrhosisinseverecases.Humanalpha-1antitrypsinprotectsthelungsfromtheharmfuleffectsofhumanneutrophilelastase.

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