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| Product Name | Complement Component 4c |
| Source | Human Plasma |
| Catalogue Number | 194-42 |
| Purity | > 85% (SDS-PAGE) |
| Form | Lyophilized |
| Protein | Reported in mg/vial (BCA) |
| Form | Lyophilized from phosphate buffered saline. |
| Recertification | 3 years |
| Storage | -20°C |
| Synonyms | C4c |
| Gene | C4A, C4B |
| Gene ID | 720, 721 |
| Gene Synonyms | DAMC-258G8.6, C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG, DADB-112B14.11-001, C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3 |
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It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis.
Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis)
Human Complement C4c is used as an immunogen and our product is an inactive form.
C4c is produced in Human plasma having a molecular mass of 210 kDa. It interacts with complement C1 and complemenet C2 to form complement C3 convertase of the classic activation pathway. Systemic lupus erythematosus is often associated with congenital complemnet C4 deficiency. Reduced levels of components of the classic pathway complement(s)(C1, C2, C4, C3) are common after such activation, Systemic lupus erythematosus , acute serum sickness and conditions associated with circulating immune complexes.
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