Small cardioactive peptide B (SCPB) is a peptide co-transmitter intrinsic to motor neurons that controls feeding behavior and muscle movement in molluscs such as species of Lymnea, Aplysia, and Clione. SCPB acts at the neuromuscular synapse, increasing cAMP; here, this peptide facilitates connection between cholinergic inhibitory neurons and sensory neurons. SCPB also controls feeding behavior, increasing feeding arousal.
| Cas No. | 84746-43-0 |
|---|---|
| Purity | ≥95% |
| Formula | C52H80N14O11S2 |
| Formula Wt. | 1141.43 |
| IUPAC Name | (2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanediamide |
| Synonym | SCPB |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | S1061 Info Sheet PDF |
|---|
Fox LE, Lloyd PE. Role of cAMP in the short-term modulation of a neuromuscular system in aplysia. J Neurophysiol. 2000 Mar;83(3):1567-79. PMID: 10712480.
Storozhuk M, Castellucci VF. Modulation of cholinergic transmission in the neuronal network of the gill and siphon withdrawal reflex in Aplysia. Neuroscience. 1999 Apr;90(1):291-301. PMID: 10188955.
Perry SJ, Dobbins AC, Schofield MG, et al. Small cardioactive peptide gene: structure, expression and mass spectrometric analysis reveals a complex pattern of co-transmitters in a snail feeding neuron. Eur J Neurosci. 1999 Feb;11(2):655-62. PMID: 10051766.
Norekian TP, Satterlie RA. Small cardioactive peptide B increases the responsiveness of the neural system underlying prey capture reactions in the pteropod mollusc, Clione limacina. J Exp Zool. 1994 Oct 1;270(2):136-47. PMID: 7999153.
Whim MD, Lloyd PE. Neuropeptide cotransmitters released from an identified cholinergic motor neuron modulate neuromuscular efficacy in Aplysia. J Neurosci. 1990 Oct;10(10):3313-22. PMID: 1976768.
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