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LKT/HEXARELIN/H1893/50 mg

ProductIDH1893
CasNo.140703-51-1
Purity≥95%
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

Hexarelinisasyntheticanalogofghrelinthatbindsandactivatestheghrelin(GHS)receptor.Hexarelinexhibitscardioprotective,anti-fibrotic,antihypertensive,andanti-fertilityactivities.Inanimalmodelsofmyocardialinfarction,hexarelinprotectscardiacfunction.Inspontaneouslyhypertensiverats,hexarelinpreventsdepositionofcollagen,decreasesexpressionofTIMP-1,collagenI,andcollagenIII,andincreasesexpressionofMMP2andMMP9,decreasingcardiacfibrosisandbloodpressureandattenuatingleftventricularhypertrophy.Hexarelinalsodecreasesovulationandnumberofoffspringproducedinvivo.

ProductInfo

CasNo.

140703-51-1

Purity

≥95%

Formula

C47H58N12O6

FormulaWt.

887.0

ChemicalName

L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-Lysinamide

IUPACName

(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamideInChI:InChI=1S/C47H58N12O6/c1-27-34(33-15-7-9-17-37(33)54-27)23-41(58-44(62)35(49)22-31-25-51-26-53-31)45(63)55-28(2)43(61)57-40(21-30-24-52-36-16-8-6-14-32(30)36)47(65)59-39(20-29-12-4-3-5-13-29)46(64)56-38(42(50)60)18-10-11-19-48/h3-9,12-17,24-26,28,35,38-41,52,54H,10-11,18-23,48-49H2,1-2H3,(H2,50,60)(H,51,53)(H,55,63)(H,56,64)(H,57,61)(H,58,62)(H,59,65)/t28-,35-,38-,39?,40-,41+/m0/s1

Synonym

Examorelin

Solubility

Solubleinwater.

Appearance

WhitetoOff-whitePowder

ShippingandStorage

StoreTemp

-20°C

ShipTemp

Ambient

Downloads

MSDS

H1893MSDSPDF

InfoSheet

H1893InfoSheetPDF

References

MaoY,TokudomeT,KishimotoI,etal.Onedoseoforalhexarelinprotectschroniccardiacfunctionaftermyocardialinfarction.Peptides.2014Apr18;56C:156-162.PMID:24747279.

XuX,DingF,PangJ,etal.ChronicadmiNISTrationofhexarelinattenuatescardiacfibrosisinthespontaneouslyhypertensiverat.AmJPhysiolHeartCircPhysiol.2012Sep15;303(6):H703-11.PMID:22842067.

PuechagutPB,MartiniAC,StutzG,etal.Reproductiveperformanceandfertilityinmaleandfemaleadultmicechronicallytreatedwithhexarelin.ReprodFertilDev.2012;24(3):451-60.PMID:22401277.

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