Molsidomine is a NO donor that exhibits vasodilatory, cardioprotective, anti-atherosclerotic, and anticoagulant activities. Molsidomine inhibits PDGF-induced smooth muscle cell migration and proliferation and suppresses carotid artery neointima formation in vivo by inhibiting activity of annexin A2. In vitro, molsidomine inhibits activated platelet adhesion.
| Cas No. | 25717-80-0 |
|---|---|
| Purity | ≥98% |
| Formula | C9H14N4O4 |
| Formula Wt. | 242.23 |
| Chemical Name | N-(Ethoxycarbonyl)-3-(4-morpholinyl)sydnone imine |
| IUPAC Name | (1E)-1-ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate |
| Synonym | Corvaton; Corvasal; Molsidolat; Morial; Motazominn |
| Melting Point | 140-141°C |
| Solubility | Soluble in chloroform, methanol, ethanol, or ethyl acetate. Slightly soluble in water, acetone or benzene. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | M5746 Info Sheet PDF |
|---|
Harnek J, Zoucas E, de Sá VP, et al. Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway. BMC Cardiovasc Disord. 2011 Jun 11;11:30. PMID: 21663688.
Won KJ, Lee P, Jung SH, et al. 3-morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration. Proteomics. 2011 Jan;11(2):193-201. PMID: 21204247.
Cardoso MH, Morganti RP, Lilla S, et al. The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion. Eur J Pharmacol. 2010 Feb 10;627(1-3):229-34. PMID: 19895807.
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