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Matreya/L<i>threo</i>Dihydrosphingosine (Safingol)/1807025/25 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Matreya/LthreoDihydrosphingosine (Safingol)/1807025/25 mg
  • Catalog#:1807-025
  • ScientificName:L-threo-Dihydrosphingosine(Safingol)
  • CommonName:L-threo-Sphinganine,C18chain
    Activity:ProteinKinaseC(PKC)andSphingosineKinaseinhibitor
  • EmpiricalFormula:C18H39NO2
  • CAS#15639-50-6
  • SDSViewSafetyDataSheet
  • DataSheet:ViewDataSheet
  • FormulaWeight:301
  • Unit:25mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • AnalyticalMethods:TLC,GC
  • MeltingPoint:103-114°C
  • Solubility:chloroform,methanol,ethanol,DMSO
  • PhysicalAppearance:solid
  • Storage:-20°C
  • DryIce:No
  • Hazardous:No
  • LiteratureReferences:
    1.Darges,etal.“InhibitionofleukotrieneB4(LTB4)inhumanneutrophilsbyL-threo-dihydrosphingosine”Adv.Exp.Med.Biol,Vol.400App.387-392,1997
    2.G.Schwartz,etal.“Apilotclinical/pharmacologicalstudyoftheproteinkinaseC-specificinhibitorsafingolaloneandincombinationwithdoxorubicin”Clin.CancerRes,Vol.3pp.537-543,1997
    3.J.Cowardetal.“Safingol(L-threo-sphinganine)inducesautophagyinsolidtumorcellsthroughinhibitionofPKCandthePI3-kinasepathway”AutophagyVol.5(2)pp.184-193,2009
    4.M.Dragusinetal.“Metabolismoftheunnaturalanticancerlipidsafingol,L-threo-dihydrosphingosine,inculturedcells”Vol.44pp.1772,2003

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