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Medchemexpress/Kartogenin(Synonyms: KGN)/HY-16268/100mg

Kartogeninisaninducerofdifferentiationofhumanmesenchymalstemcellsintochondrocytes.
Description

Kartogeninisaninducerofdifferentiationofhumanmesenchymalstemcellsintochondrocytes.

InVitro

Kartogeninenhancescellproliferationinbothcelltypesinaconcentration-dependentmannerandinduceschondrogenicdifferentiationofstemcells,asdemonstratedbyhighexpressionlevelsofchondrogenicMarkersaggrecan,collagenIIandSox-9.Besides,kartogenininducestheformationofcartilage-liketissuesincellcultures,asobservedthroughthestainingofabundantproteoglycans,collagenIIandosteocalcin[1].Kartogeninstimulatestype-IcollagensynthesisoffibroblastsatthemRNAandproteinlevelsinatime-dependentmannerwithoutobviousinfluenceonfibroblasts’apoptosisandviABIlity.Smad4/smad5oftheTGF-βsignalingpathwayisactivatedbykartogeninwhileMAPKsignalingpathwayremainsunchanged[2].KartogenintreatmentenhanceschondrocytepericellularmatrixassemblyandretentioninthepresenceofIL-1β.KartogeninpartiallyblockstheIL-1β-inducedincreasedexpressionofADAMTS-5.Additionally,kartogenin-treatedarticularchondrocytesexhibitsadecreaseinCD44proteolyticfragmentation[3].

InVivo

heninjectedintointactratpatellartendons,kartogenininducescartilage-liketissueformationintheinjectedarea.WheninjectedintoexperimentallyinjuredratAchillesTBJs,woundhealingintheTBJsisenhanced,asevidencedbytheformationofextensivecartilage-liketissues[1].Kartogeninstimulatescollagensynthesisinthemousedermis.Dermisinthekartogenin(100nM)-treatedgroupexhibitsincreaseddermalthicknessandintensebluestaining,whichrepresentsmorecollagencompositioninthedermis[2].

PreparingStockSolutions
ConcentrationVolumeMass1mg5mg10mg
1mM3.1512mL15.7560mL31.5119mL
5mM0.6302mL3.1512mL6.3024mL
10mM0.3151mL1.5756mL3.1512mL
Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent.
CellAssay
[1]

RabbitBMSCsorPTSCsaretreatedwithvariousconcentrations(1nMto5μM)ofkartogenin.Themediumischangedevery3daysandafter2weeks,cellproliferationismeasuredbypopulationdoublingtime[1].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

AnimalAdmiNISTration
[1]

Rat:Thenratsaredividedintotwogroupsbasedontheinjectionsreceived:sixratsaregiven10µLsalineinjectionsineachwound(wound-onlygroup)andsixratsreceive10µLof100µMkartogeninsolutioneachinthewoundedareas(wound+kartogeningroup).Theinjectionsaregivenimmediatelyafterwoundingandrepeatedondays2,4,7and12[1].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

MolecularWeight

317.34

Formula

C₂₀H₁₅NO₃

CASNo.

4727-31-5

Storage
Powder-20°C3years
 4°C2years
Insolvent-80°C6months
 -20°C1month
Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

DMSO:≥42mg/mL

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:>98.0%