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生物学描述
Prototypic P2X7 receptor agonist, showing 5-10 fold greater potency than ATP (pEC50 = 6.5). Also exhibits activity at other P2 receptors (EC50 values are 5 and 63 M at P2X3 and P2Y11, respectively). Shows high potency at P2X1 receptor (pEC50 = 8.7). Potent activator of cAMP production.
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES
CCN(CC)CC.C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)C(=O)O[C@@H]3[C@H](O[C@H]([C@@H]3O)N4C=NC5=C(N=CN=C54)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O
2D chemical structure image of ab120444, BzATP triethylammonium salt, prototypic P2X7 agonist. P2 agonist.
To our knowledge, customised protocols are not required for this product.
Please try the standard protocols listed below and let us know how you get on.
Click here to view the general protocols
发表研究结果有使用 ab120444?请让我们知道,以便我们可以引用本数据表中的参考文章。
ab120444 被引用在 2 文献中.
Wang F et al. Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity. EBioMedicine 30:303-316 (2018).
PubMed: 29463472
Toulme E et al. P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin. J Gen Physiol 135:333-53 (2010).
PubMed: 20231374
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