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MedKoo Biosciences/Dorzolamide hydrochloride/315352/200mg

Dorzolamide(tradenameTrusopt)isacarbonicanhydraseinhibitor.Itisananti-glaucomaagentandtopicallyappliedintheformofeyedrops.Thisdrug,developedbyMerck,wasthefirstdruginhumantherapy(marketintroduction1995)whichresultedfromstructure-baseddrugdesign.Dorzolamidehydrochlorideisusedtolowerincreasedintraocularpressureinopen-angleglaucomaandocularhypertension.ThecombinationofdorzolamidewithtimololismarketedunderthetradenameCosopt.

MedKooCat#:315352
Name:Dorzolamidehydrochloride
CAS#:130693-82-2
ChemicalFormula:C10H17ClN2O4S3
ExactMass:
MolecularWeight:360.9
ElementalAnalysis:C,33.28;H,4.75;Cl,9.82;N,7.76;O,17.73;S,26.65


Synonym:TRUSOPT;(2S4S)2Ethylamino4methyl55dioxo57dithiABIcyclo4.3.0nona810diene8sulfonamidehydrochloride;(4Strans)4(ethylamino)56dihydro6methyl4Hthieno23bthiopyran2sulfonamide77dioxidemonohydrochloride.

IUPAC/ChemicalName:(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide7,7-dioxidehydrochloride

InChiKey:OSRUSFPMRGDLAG-QMGYSKNISA-N

InChiCode:InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1

SMILESCode:O=S(C(S1)=CC([C@@H](NCC)C[C@@H]2C)=C1S2(=O)=O)(N)=O.[H]Cl


TechnicalData

Appearance:
Solidpowder

Purity:
>98%(orrefertotheCertificateofAnalysis)

ShippingCondition:
Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:
Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:
SolubleinDMSO.

ShelfLife:
>2yearsifstoredproperly

DrugFormulation:
ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:
0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:
293490


References

1:KobayashiM,NaitoK.[Pharmacologicalprofilesofthepotentcarbonicanhydraseinhibitordorzolamidehydrochloride,atopicalantiglaucomaagent].NihonYakurigakuZasshi.2000Jun;115(6):323-8.Review.Japanese.PubMedPMID:10948564.

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