MedKoo Biosciences/Alfacalcidol/315127/10mg

Synonym:

IUPAC/ChemicalName:(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

InChiKey:OFHCOWSQAMBJIW-DWKIUPLPSA-N

InChiCode:InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-

SMILESCode:CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C

TechnicalData

References

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2:FukuiT,MunemuraC,MaetaS,IshidaC,MurawakiY.TheEffectsofOlmesartanandAlfacalcidolonRenoprotectionandklothoGeneExpressionin5/6NephrectomizedSpontaneouslyHypertensiveRats.YonagoActaMed.2011Sep;54(3):49-58.Epub2011Sep1.Review.PubMedPMID:24031129;PubMedCentralPMCID:PMC3763788.

3:KuboderaN.D-hormonederivativesforthetreatmentofosteoporosis:fromalfacalcidoltoeldecalcitol.MiniRevMedChem.2009Oct;9(12):1416-22.Review.PubMedPMID:19929815.

4:KuboderaN.AnewlookatthemostsuccessfulprodrugsforactivevitaminD(Dhormone):alfacalcidolanddoxercalciferol.Molecules.2009Sep29;14(10):3869-80.doi:10.3390/molecules14103869.Review.PubMedPMID:19924035.

5:O'DonnellS,MoherD,ThomasK,HanleyDA,CranneyA.Systematicreviewofthebenefitsandharmsofcalcitriolandalfacalcidolforfracturesandfalls.JBoneMinerMetab.2008;26(6):531-42.doi:10.1007/s00774-008-0868-y.Epub2008Nov1.Review.PubMedPMID:18979152.

6:SaitoM.[Assessmentofbonequality.Effectsofbisphosphonates,raloxifene,alfacalcidol,andmenatetrenoneonbonequality:collagencross-links,mineralization,andmicrodamage].ClinCalcium.2008Mar;18(3):364-72.doi:CliCa0803364372.Review.Japanese.PubMedPMID:18310825.

7:RingeJD,SchachtE.ImprovingtheoutcomeofestablishedtherapiesforosteoporosisbyaddingtheactiveD-hormoneanalogalfacalcidol.RheumatolInt.2007Dec;28(2):103-11.Epub2007Aug1.Review.PubMedPMID:17668216.

8:RoseryH,BergemannR,MarxSE,BoehnkeA,MelnickJ,SterzR,WilliamsL.Health-economiccomparisonofparicalcitol,calcitriolandalfacalcidolforthetreatmentofsecondaryhyperparathyroidismduringhaemodialysis.ClinDrugInvestig.2006;26(11):629-38.Review.PubMedPMID:17163297.

9:SchachtE,RichyF,ReginsterJY.Thetherapeuticeffectsofalfacalcidolonbonestrength,musclemetabolismandpreventionoffallsandfractures.JMusculoskeletNeuronalInteract.2005Jul-Sep;5(3):273-84.Review.PubMedPMID:16172518.

10:ScharlaSH,SchachtE,LempertUG.AlfacalcidolversusplainvitaminDininflammationinducedboneloss.JRheumatolSuppl.2005Sep;76:26-32.Review.PubMedPMID:16142848.