产品资料

MedKoo Biosciences/SGC-CBP30/406442/10mg

SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. CREBBP has also been associated with Amyotrophic Lateral Sclerosis (ALS) or Lou GehrigÂ’s disease, a neurodegenerative disease with progressive degeneration of motor neurons in the brain and spinal cord, Alzheimer's disease and poly glutamine repeat diseases such as Spinal and Bulbar Muscular Atrophy and HuntingtonÂ’s disease. (http://www.thesgc.org/chemical-probes/SGC-CBP30).

MedKoo Cat#: 406442
Name: SGC-CBP30
CAS#: 1613695-14-9
Chemical Formula: C28H33ClN4O3
Exact Mass: 508.22412
Molecular Weight: 509.03962
Elemental Analysis: C, 66.07; H, 6.53; Cl, 6.96; N, 11.01; O, 9.43

Synonym: SGC-CBP30; SGC-CBP 30; SGC-CBP-30.

IUPAC/Chemical Name: (S)-4-(1-(2-(3-chloro-4-methoxyphenethyl)-5-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-1-yl)propan-2-yl)morpholine

SMILES Code: C[C@H](N1CCOCC1)CN2C(CCC3=CC=C(OC)C(Cl)=C3)=NC4=CC(C5=C(C)ON=C5C)=CC=C24

Technical Data

Appearance:

white to off-white solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

View CoA: current batch, Lot#BBC70103

QC Data:

View QC data: current batch, Lot#BBC70103

Safety Data Sheet (MSDS):

View Material Safety Data Sheet (MSDS)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

293490

Additional Information

CREBBP (CBP) and EP300 are involved in many biological processes like maintenance of genomic stability by affecting DNA replication and DNA repair as well as cell growth, transformation and development. They also play and essential role in neuronal plasticity/ memory formation hematopoiesis and energy homeostasis as demonstrated in a variety of mouse models. They possess both acetyl-transferase enzymatic and bromodomain containing regions. Through acetylation of non-histone proteins CREBBP can have a positive or negative effect on transcriptional regulation by affecting protein- protein interactions, protein-DNA interactions, nuclear retention or protein half-life. (http://www.thesgc.org/chemical-probes/SGC-CBP30).

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MedKoo Biosciences/SGC-CBP30/406442/10mg

Technical Data

Additional Information

References