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Figure 626, The RNA splicing reaction Molecular Biology of the Cell NCBI Bookshelf188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Figure 626, The RNA splicing reaction Molecular Biology of the Cell NCBI Bookshelf
Figure6-26,TheRNAsplicingreaction-MolecularBiologyoftheCell-NCBIBookshelf
Figure 6-26. The RNA splicing reaction.Figure6-26TheRNAsplicingreaction

(A)Inthefirststep,aspecificadeninenucleotideintheintronsequence(indicatedinred)attacksthe5splicesiteandcutsthesugar-phosphatebackboneoftheRNAatthispoint.Thecut5endoftheintronbecomescovalentlylinkedtotheadeninenucleotide,asshownindetailin(B),therebycreatingaloopintheRNAmolecule.Thereleasedfree3-OHendoftheexonsequencethenreactswiththestartofthenextexonsequence,joiningthetwoexonstogetherandreleasingtheintronsequenceintheshapeofalariat.Thetwoexonsequencestherebybecomejoinedintoacontinuouscodingsequence;thereleasedintronsequenceisdegradedinduecourse.

From:FromDNAtoRNA

Cover of Molecular Biology of the CellMolecularBiologyoftheCell.4thedition.AlbertsB,JohnsonA,LewisJ,etal.NewYork:GarlandScience;2002.Copyright©2002,BruceAlberts,AlexanderJohnson,JulianLewis,MartinRaff,KeithRoberts,andPeterWalter;Copyright©1983,1989,1994,BruceAlberts,DennisBray,JulianLewis,MartinRaff,KeithRoberts,andJamesD.Watson.

NCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.


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