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美国的Nanoprobes公司（http://www.nanoprobes.com/）应用金标记和先进的控制方式和位置，非常适合纳米生物技术和纳米结构材料。
EnzMet™
EnzMet™(EnzymeMetallography)isa newBIOLOGicallabelingandstainingmethod developedatNanoprobes,which usesatargetedenzymaticprobewithanovelmetallographicsubstratetoprovideaquantumleapinstainingclarityoverconventionalchromogenicandfluorescentsubstrates forimmunohistochemistry(IHC)and insitu hybridization(ISH)applications.IthasprovenhighlysensitivebothforISH,whereitreADIlyvisualizesendogenouscopiesofsinglegenes,andimmunohistochemistry(IHC)detection.Ithasalsobeenusedasanelectricaldetectionmethodforbiochips.
GoldIBLot™
Goldiblot™HisDetectionKitisarapid,sensitivealternativetoenzymaticmethodsforthedetectionofrecombinantHis-taggedproteins onmembraneblotssuchasimmunoblotsandwesterns.Itusesnitrilotriaceticacid(NTA)-nickel(II)-functionalizedgoldnanoparticles,whichbindtightlyandselectivelytoHistags,followedby metalenhancementfordirectvisualization.