企业QQ
官方微信
Mousemonoclonalantibody
Theantigenis asyntheticpeptidefromN-terminalregionofmousenorepinephrinetransporter.
TheantibodyisProteinGpurifiedculturesupernatant.
NorepinephrineTransporter[NET](ornoradrenalinetransporter(NAT))isamonoaminetransporterthattransportstheneurotransmitternoradrenalinefromthesynapsebacktoitsvesiclesforstorageuntillateruse.Italsoappearstotransporttheneurotransmitterdopamineinthesameway,buttoalesserdegree.StudieshaveshownadecreaseinNETlevelsinthelocuscoeruleusinpatientsdiagnosedwithmajordepression(Klimeketal.,1997).Cocaine,amphetaminesandmanytherapeuticantidepressants,suchastheSNRIs(SEROtonin-norepinephrinereuptakeinhibitors)andthetricyclicantidepressants(TCAs)acttoraisenoradrenaline.FurThermore,deficitsintheNETgenehavebeenassociatedwithADHD(Kimetal.,2006).
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternblots.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforuptooneyearafterdateofreceipt.Avoidfreeze/thawcycles.
Andreoli,M.,Marketkar,T.andDimitrov,E.,2017.ContributionofamygdalaCRFneuronstochronicpain.ExperimentalNeurology,298,pp.1-12.PMID:28830762