BSAbioinspired gold nanorods loaded with immunoadjuvant for the treatment of melanoma by combined photothermal therapy and immunotherapy_

摘要：

Thedevelopmentoftherapeuticmethodsthatcaneffectivelydelaytumorgrowth,inhibittumormetastases,andprotectthehostfromtumorrecurrencestillfaceschallenges.Nanoparticle-basedcombinationtherapymayprovideaneffectivetherapeuticstrategy.Herein,weshowthatbovineserumalbumin(BSA)-bioinspiredgoldnanorods(GNRs)wereloadedwithanimmunoadjuvantforcombinedphotothermaltherapy(PTT)andimmunotherapyforthetreatmentofmelanoma.Inthiswork,cetyltrimethylammoniumbromide(CTAB)-coatedGNRsweresuccessivelydecoratedwithpolyethyleneglycol(PEG)andBSA,andloadedwithanimmunoadjuvantimiquimod(R837).ThesynthesizedmPEG-GNRs@BSA/R837nanocomplexesundernear-infrared(NIR)irradiationcouldeffectivelykilltumorsandtriggerstrongimmuneresponsesintreatingmetastaticmelanomainmice.Furthermore,thenanocomplex-basedPTTpreventedlungmetastasisandinducedastronglong-termantitumorimmunitytoprotectthetreatedmicefromtumorrecurrence.Thenanocomplex-basedPTTincombinationwithimmunotherapymaybepotentiallyemployedasaneffectivestrategyforthetreatmentofmelanomaandothermetastaticcancers.

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