Details: | |
TestedApplications | ELISA |
TargetInformation | BotulinumneurotoxintypeAisa149.45kDaneurotoxin |
ProductFormat | AffinityPurified |
AlternateNames | BotulinumneurotoxintypeA,Bontoxilysin-A,BOTOX,botA,bna |
Clone | Multiple |
Host | Mouse |
Isotype | Ig |
Immunogen | RecombinantProtein |
Epitope | a.a.870-1295 |
Relevance | Inhibitsacetylcholinerelease.ThebotulinumtoxinbindswithhighaffinitytoperipheralneuronalpresynapticmembranetothesecretoryvesicleproteinSV2.ItbindsdirectlytothelargestluminalloopofSV2A,SV2BandSV2C.Itistheninternalizedbyreceptor-mediatedendocytosis.TheC-terminusoftheheavychain(H)isresponsIBLefortheadherenceofthetoxintothecellsurfacewhiletheN-terminusmediatestransportofthelightchainfromtheendocyticvesicletothecytosol.Aftertranslocation,thelightchain(L)hydrolyzesthe197-Gln-|-Arg-198bondinSNAP-25,therebyblockingneurotransmitterrelease.Inhibitionofacetylcholinereleaseresultsinflaccidparalysis,withfrequentheartorrespiratoryfailure. |
Specificity | BotulinumneurotoxinA1 |
ReportedReactivity | Unknown |
ReportedApplications | Unknown |
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