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| Details: | |
| Tested Applications | WB, ELISA |
| Target Information | S100B is a 10.7kDa calcium & zinc binding protein expressed in astrocytes |
| Product Format | Affinity purified |
| Alternate Names | S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B |
| Clone | 14H2D10, 7H5H10, 11H10F7, 6F11G9, 4E10A11, 3G4D12, 11C12E12, 5D5D7, 15C10H11, 15A9G5 |
| Host | Mouse |
| Isotype | IgG1 |
| Immunogen | Recombinant protein |
| Epitope | Unknown |
| Relevance | S100B is glial-specific and is expressed primarily by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is only expressed by a subtype of mature astrocytes that ensheath blood vessels and by NG2-expressing cells.This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing CNS it acts as a neurotrophic factor and neuronal survival protein. In the adult organism it is usually elevated due to nervous system damage, which makes it a potential clinical marker. S100B is secreted by astrocytes or can spill from injured cells and enter the extracellular space or bloodstream. Serum levels of S100B increase in patients during the acute phase of brain damage. Over the last decade, S100B has emerged as a candidate peripheral biomarker of blood–brain barrier (BBB) permeability and CNS injury. |
| Specificity | Human S100B |
| Reported Reactivity | Unknown |
| Reported Applications | Unknown |
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