Rat/Mouse Myelinoligodendrocyte glycoprotein (MOG) 3555 Peptides

公司介绍：美国GenemedSynthesisInc公司，于1994年成立于旧金山，是美国知名的生命科学实验室试剂产品生产厂家，主要产品为抗体，多肽，试剂盒，蛋白质和DNA合成服务等，由于公司发展需要，2007年搬迁到圣安东尼奥市，公司进入了快速全面的发展阶段，产品已经服务于世界各地。

产  品：Myelin-oligodendrocyteglycoprotein(MOG)isamemberofthe immunoglobulin(Ig)superfamily,exclusivelyexpressedinthecentral nervoussystem(CNS).MOGisanintrinsicmembraneprotein characterizedbyaN-terminalextracellularimmunoglobulin-like variable(Ig-likeV-type)domain,twohydrophobictransmembrane
domainsandacytoplasmicC-terminalregion.TheN-terminalMOG domainhasstronghomologywiththeN-terminusofbutyrophilin,a proteinexpressedinthelactatingmammarygland.HumanMOGgene islocalizedtochromosome6p22-p21.3(bandCofmouse chromosome17)atthedistalendoftheMHCclassIbregion.Despite
thesimilarnames,oligodendrocyte-myelinglycoprotein(OMG)is aseparateproteinencodedwithinalargeintronoftheNF1gene. The2glycoproteinsareassociatedspecificallywitholigodendrocytes andmyelin,buthavequitedifferentrolesinmyelinogenesisandare structurallyunrelated.MOGisanintrinsicmembranemoleculewith2 transmembranedomains,whereasOMGisanchoredintheouter leafletoftheplasmamembranethroughaglycophospholipidtail.OMG belongstothefamilyofproteinswithaseriesoftandemleucine-rich
repeats,whileMOGisamemberoftheIgsuperfamily.

MOGcontainsnineexonsandeightseparatingintrons,givingrise toatleasteightalternativelysplicedvariantsencodingforthe MOG-alpha1-4andMOG-beta1-4isoforms(16-26kDa).The differentMOGisoformsmayinteracttoformhomo-and heterodimersandtrimers(55and78kDa).Duringthelaststepof myelinogenesis,MOGisexpressedintheCNSontheoutermost surface(externallamella)ofmaturemyelinsheathsandonthecell surfaceofmyelinatingoligodendrocytes.MOGhasavarietyof functionsincludingaroleasacellularadhesionmolecule.Itmay beinvolvedalsointhecompletionand/ormaintenanceofthe myelinsheathandincell-cellcommunication.MOGisalsothought tofunctionasaregulatorofoligodendrocytemicrotubulestABIlity andasamediatorofinteractionsbetweenmyelinandtheimmune systeminthecomplementcascade.AlthoughMOGisarelatively minorcomponentofthemyelinmembrane,itisaprimaryautoantigen targetinvolvedinthepathogenesisofimmune-mediated demyelinatingdiseasesincludingexperimentalautoimmune
encephalomyelitis(EAE)andmultiplesclerosis. TheMOG35-55peptideisanimmunodominantepitopeofMOG
thatinducesstrongTandBcellresponses.Asingleinjectionof thispeptidefragmentcanproduceanexacerbating-remitting neurologicdiseasewithextensiveplaque-likedemyelination,which mayserveasamodelforinvestigatingmultiplesclerosis.
 

HumanMOGIsoforms,Comments Accession#	Comments
Alpha-1,Q16653-1	Membraneprotein1-247aa(1-29 signal;maturechain30-247),30-154 Extracellular;32-145Ig-likeV-type; 155-175TM1;176-210cytoplasmic domain1;211-231TM2;232-247EC2
Alpha-2,Q16653-2	198-236missing
Alpha-3,Q16653-3	198-236 DPHFLRVPCWKITLFVIVPVLGPLVAL IICYNWLHRRLA-> ESFGVLGPQVKEPKKT(inisoform3 andisoform7
Alpha-4,Q16653-4	30-145missing;
beta-1,Q16653-5	Membraneproteins;244-247RNPF-> LFHLEALSG
beta-2,Q16653-6	198-236missing;244-247RNPF-> LFHLEALSG
beta-3,Q16653-7	198-236 DPHFLRVPCWKITLFVIVPVLGPLVAL IICYNWLHRRLA-> ESFGVLGPQVKEPKKT(inisoform3 andisoform7;244-247RNPF-> LFHLEALSG
beta-4,Q16653-8	198-243missing;244-247RNPF-> LFHLEALSG;244-247RNPF-> LFHLEALSG
Q16653-9	Notfunctionallyactive;198-203 DPHFLR->GKFRHV;209-247 missing;

 
Cat#MOG3555-P-5
Sequence:MEVGWYRSPFSRVVHLYRNGK
MolWt:2582
Formula:C118H177N35O29S
Form:PowderSolubility:Water(1mg/ml)
Storage:Storepowderat-20oCforupto6months.

Afterreconstitutioninwater,storesolutioninsmallaliquotsat-20oCfor3-6months.Donotfreezeandthaworstorediluted solutions.

GeneralReferences（文献）:Pham-Dinh,D(1995)Genomics29:345-352;Pham-Dinh,D.(1995)Immunogenetics42:386-391;Pham-Dinh,D(1993)PNAS90:7990-7994;Roth,M.-P(1995)Genomics 28:241-250;IchikawaM(1996)J.Immunol.157,919-926;BernardCC(1997)J.Mol.Med.75,77-87;SlavinA(1998) Autoimmunity28,109-120


AntibodiestoMOG35-55,andMOGautoantibodiesdetectionkitMOG3555-P-570318A